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Randomized Controlled Trial
. 2020 Dec 18;49(4):480-484.
doi: 10.1515/jpm-2020-0318. Print 2021 May 26.

Effect of vitamin D3 supplementation during pregnancy on high risk factors - a randomized controlled trial

Jiang Xiaomang  1 , Wei Yanling  2
Affiliations
Randomized Controlled Trial

Effect of vitamin D3 supplementation during pregnancy on high risk factors - a randomized controlled trial

Jiang Xiaomang et al. J Perinat Med. .

Abstract

Objectives: Vitamin D plays an important role in the release of the placenta and implantation, and low levels are a risk factor for pre-eclampsia. Studies have also shown that symptomatic treatment of vitamin D3 deficiency can effectively reduce the risk of pre-eclampsia. In this study, vitamin D3 supplementation was performed on the risk of pre-eclampsia to observe its effect.

Methods: From January 2016 to December 2018, 450 women with maternal treatment and delivery in our hospital underwent an open-label randomized study. The pregnant women were divided into low-dose, medium-dose, and high-dose groups. Compare the incidence of pre-eclampsia and the dose effect of vitamin D levels.

Results: In the maternal and perinatal periods of the 450 maternal women, the 25[OH] index of the three groups of pregnant women was significantly increased, while the high-dose increase index was more obvious. The relative risk reduction rate was significantly lower. Compared with the low-dose and middle-dose groups, the high-dose group had a significantly lower incidence of pre-eclampsia, while the IUGR index was lower, and other obstetric indicators were comparable.

Conclusion: Vitamin D supplementation can effectively reduce the incidence of pre-eclampsia, while reducing the IUGR index, which has important value and significance in its clinical application.

Keywords: pre-eclampsia; pregnancy; vitamin D3.

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References

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