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. 2021;80(1):459-469.
doi: 10.3233/JAD-201184.

Mild Behavioral Impairment and Subjective Cognitive Decline Predict Cognitive and Functional Decline

Zahinoor Ismail  1   2   3   4   5 , Alexander McGirr  1   4 , Sascha Gill  4 , Sophie Hu  4 , Nils D Forkert  2   4   6 , Eric E Smith  2   3   4   6
Affiliations

Mild Behavioral Impairment and Subjective Cognitive Decline Predict Cognitive and Functional Decline

Zahinoor Ismail et al. J Alzheimers Dis. 2021.

Abstract

Background: Mild behavioral impairment (MBI) and subjective cognitive decline (SCD) are dementia risk states, and potentially represent neurobehavioral and neurocognitive manifestations, respectively, of early stage neurodegeneration. Both MBI and SCD predict incident cognitive decline and dementia, are associated with known dementia biomarkers, and are both represented in the NIA-AA research framework for AD in Stage 2 (preclinical disease).

Objective: To assess the associations of MBI and SCD, alone and in combination, with incident cognitive and functional decline in a population of older adults. We tested the hypothesis that MBI and SCD confer additive risk for decline.

Methods: Cognitively normal participants were followed up annually at Alzheimer's Disease Centers. Logistic regression assessed the relationship between baseline classification (MBI-SCD-, MBI-SCD+, MBI+SCD-, or MBI+SCD+) and 3-year outcome.

Results: Of 2,769 participants (mean age=76), 1,536 were MBI-SCD-, 254 MBI-SCD+, 743 MBI+SCD-, and 236 MBI+SCD+. At 3 years, 349 (12.6%) declined to CDR >0, including 23.1% of the MBI+group, 23.5% of the SCD+group, and 30.9% of the intersection group of both MBI+and SCD+participants. Compared to SCD-MBI-, we observed an ordinal progression in risk (ORs [95% CI]): 3.61 [2.42-5.38] for MBI-SCD+ (16.5% progression), 4.76 [3.57-6.34] for MBI+SCD- (20.7%), and 8.15 [5.71-11.64] for MBI+SCD+(30.9%).

Conclusion: MBI and SCD together were associated with the greatest risk of decline. These complementary dementia risk syndromes can be used as simple and scalable methods to identify high-risk patients for workup or for clinical trial enrichment.

Keywords: Mild behavioral impairment; mild cognitive impairment; neuropsychiatric symptoms; preclinical Alzheimer’s disease; subjective cognitive decline.

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Conflict of interest statement

Authors’ disclosures available online (https://www.j-alz.com/manuscript-disclosures/20-1184r2).

Figures

Fig. 1
Fig. 1
Cognitive and behavioral pre-dementia risk axes.
Fig. 2
Fig. 2
Flowchart of participants from NACC included for analysis.
Fig. 3
Fig. 3
Odds of CDR >0 after three years versus MBI/SCD grouping.
Fig. 4
Fig. 4
CDR score at follow up (baseline CDR=0).
Fig. 5
Fig. 5
Odds of dementia (CDR ≥1) after 3 years versus MBI/SCD grouping. Adjusted Odds Ratios (AORs) are adjusted for age, sex, ethnicity, and hypertension.
See this image and copyright information in PMC

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