Response to Letter on use of functional imaging by 11C-metomidate PET for primary aldosteronism subtyping

Minna Soinio^{1

2}, Anna-Kaarina Luukkonen³, Marko Seppänen^{2

4}, Jukka Kemppainen^{2

4}, Janne Seppänen⁵, Juha-Pekka Pienimäki⁵, Helena Leijon⁶, Tiina Vesterinen^{6

7}, Johanna Arola⁶, Eila Lantto⁸, Semi Helin², Ilkka Tikkanen⁹, Saara Metso³, Tuomas Mirtti^{6

10}, Ilkka Heiskanen¹¹, Leena Norvio¹², Mirja Tiikkainen¹², Tuula Tikkanen¹³, Timo Sane¹², Matti Välimäki¹², Celso E Gomez-Sanchez¹⁴, Ilkka Pörsti³, Pirjo Nuutila^{1

2}, Pasi I Nevalainen³, Niina Matikainen^{12

15}

Affiliations

¹ Department of Endocrinology, Turku University Hospital, Turku, Finland.
² Turku PET Centre, University of Turku, Turku, Finland.
³ Department of Internal Medicine and Tampere University, Tampere University Hospital, Faculty of Medicine and Health Technology, Tampere, Finland.
⁴ Department of clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
⁵ Centre for Vascular Surgery and Interventional Radiology, Tampere University Hospital, Tampere, Finland.
⁶ Department of Pathology, University of Helsinki and HUSLAB, Helsinki University Hospital, Helsinki, Finland.
⁷ Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
⁸ Medical Imaging Center, Radiology, Helsinki University Hospital, Helsinki, Finland.
⁹ Abdominal Center, Nephrology, University of Helsinki, and Helsinki University Hospital, and Minerva Institute for Medical Research, Helsinki, Finland.
¹⁰ Research Program in Systems Oncology (ONCOSYS), University of Helsinki, Helsinki, Finland.
¹¹ Endocrine Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
¹² Endocrinology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
¹³ Internal Medicine Outpatient Clinics, Helsinki, Finland.
¹⁴ G.V. (Sonny) Montgomery VA Medical Center and Department of Pharmacology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
¹⁵ Research Programs Unit, Clinical and Molecular Medicine, University of Helsinki, Helsinki, Finland.

PMID: 33555271
PMCID: PMC8045446
DOI: 10.1530/EJE-21-0048

Comment

Response to Letter on use of functional imaging by 11C-metomidate PET for primary aldosteronism subtyping

Minna Soinio et al. Eur J Endocrinol. 2021 Mar.

. 2021 Mar;184(3):L11-L12.

doi: 10.1530/EJE-21-0048.

Authors

Affiliations

¹ Department of Endocrinology, Turku University Hospital, Turku, Finland.
² Turku PET Centre, University of Turku, Turku, Finland.
³ Department of Internal Medicine and Tampere University, Tampere University Hospital, Faculty of Medicine and Health Technology, Tampere, Finland.
⁴ Department of clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
⁵ Centre for Vascular Surgery and Interventional Radiology, Tampere University Hospital, Tampere, Finland.
⁶ Department of Pathology, University of Helsinki and HUSLAB, Helsinki University Hospital, Helsinki, Finland.
⁷ Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
⁸ Medical Imaging Center, Radiology, Helsinki University Hospital, Helsinki, Finland.
⁹ Abdominal Center, Nephrology, University of Helsinki, and Helsinki University Hospital, and Minerva Institute for Medical Research, Helsinki, Finland.
¹⁰ Research Program in Systems Oncology (ONCOSYS), University of Helsinki, Helsinki, Finland.
¹¹ Endocrine Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
¹² Endocrinology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
¹³ Internal Medicine Outpatient Clinics, Helsinki, Finland.
¹⁴ G.V. (Sonny) Montgomery VA Medical Center and Department of Pharmacology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
¹⁵ Research Programs Unit, Clinical and Molecular Medicine, University of Helsinki, Helsinki, Finland.

PMID: 33555271
PMCID: PMC8045446
DOI: 10.1530/EJE-21-0048

No abstract available

PubMed Disclaimer

Conflict of interest statement

Declaration of interest

The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of this article.

Comment on

Functional imaging by 11C-metomidate PET: a really useless technique for primary aldosteronism subtyping?
Crimì F, Spimpolo A, Cecchin D, Rossi GP. Crimì F, et al. Eur J Endocrinol. 2021 Mar;184(3):L9-L10. doi: 10.1530/EJE-20-1402. Eur J Endocrinol. 2021. PMID: 33555270 No abstract available.

References

1. Crimi F, Spimpolo A, Cecchin D & Rossi GP. Functional imaging by 11C-metomidate PET: a really useless technique for primary aldosteronism subtyping. European Journal of Endocrinology 2021. 184 L9–L10. (10.1530/EJE-20-1402) - DOI - PubMed
1. Soinio M, Luukkonen AK, Seppänen M, Kemppainen J, Seppänen J, Pienimäki JP, Leijon H, Vesterinen T, Arola J, Lantto E et al. Functional imaging with 11C-metomidate PET for subtype diagnosis in primary aldosteronism. European Journal of Endocrinology 2020. 183 539–550. (10.1530/EJE-20-0532) - DOI - PMC - PubMed
1. Burton TJ, Mackenzie IS, Balan K, Koo B, Bird N, Soloviev DV, Azizan EA, Aigbirhio F, Gurnell M & Brown MJ. Evaluation of the sensitivity and specificity of 11C-metomidate positron emission tomography (PET)-CT for lateralizing aldosterone secretion by Conn’s adenomas. Journal of Clinical Endocrinology and Metabolism 2012. 97 100–109. (10.1210/jc.2011-1537) - DOI - PubMed
1. Newton MA & Laragh JH. Effects of glucocorticoid administration on aldosterone excretion and plasma renin in normal subjects, in essential hypertension and in primary aldosteronism. Journal of Clinical Endocrinology and Metabolism 1968. 28 1014–1022. (10.1210/jcem-28-7-1014) - DOI - PubMed
1. Inoue K, Yamazaki Y, Kitamoto T, Hirose R, Saito J, Omura M, Sasano H & Nishikawa T. Aldosterone suppression by dexamethasone in patients with KCNJ5-mutated aldosterone-producing adenoma. Journal of Clinical Endocrinology and Metabolism 2018. 103 3477–3485. (10.1210/jc.2018-00738) - DOI - PubMed

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Response to Letter on use of functional imaging by 11C-metomidate PET for primary aldosteronism subtyping

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Response to Letter on use of functional imaging by 11C-metomidate PET for primary aldosteronism subtyping

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