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. 1988 Mar 30;151(3):1173-9.
doi: 10.1016/s0006-291x(88)80489-3.

5-Hydroxymethylcytosine DNA glycosylase activity in mammalian tissue

S V Cannon  1 , A Cummings, G W Teebor
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Free article

5-Hydroxymethylcytosine DNA glycosylase activity in mammalian tissue

S V Cannon et al. Biochem Biophys Res Commun. .
Free article

Abstract

The enzymatic release of 5-hydroxymethylcytosine from T2 bacteriophage DNA was effected by an extract of calf thymus. Like the previously described 5-hydroxymethyluracil DNA glycosylase, 5-hydroxymethylcytosine DNA glycosylase was not detectable in bacterial extracts. The phylogenetic distribution of these activities indicates that their primary function is the maintenance of methylcytosine residues in differentiated tissue.

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