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Review
. 2021 Feb 4;11(2):101.
doi: 10.3390/jpm11020101.

Salivary Micro-RNA and Oral Squamous Cell Carcinoma: A Systematic Review

Maria Menini  1 , Emanuele De Giovanni  1 , Francesco Bagnasco  1 , Francesca Delucchi  1 , Francesco Pera  2 , Domenico Baldi  1 , Paolo Pesce  1
Affiliations
Review

Salivary Micro-RNA and Oral Squamous Cell Carcinoma: A Systematic Review

Maria Menini et al. J Pers Med. .

Abstract

Oral squamous cell carcinoma (OSCC) is a widespread malignancy with high mortality. In particular, a delay in its diagnosis dramatically decreases the survival rate. The aim of this systematic review was to investigate and summarize clinical results in the literature, regarding the potential use of salivary microRNAs (miRNAs) as diagnostic and prognostic biomarkers for OSCC patients. Twelve papers were selected, including both case-control and cohort studies, and all of them detected significantly dysregulated miRNAs in OSCC patients compared to healthy controls. Based on our results, salivary miRNAs might provide a non-invasive and cost-effective method in the diagnosis of OSCC, and also to monitor more easily its evolution and therapeutic response and therefore aid in the establishment of specific therapeutic strategies.

Keywords: biomarker; diagnosis; miRNAs; oral squamous cell carcinoma; prognosis; saliva.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Preferred reporting of systematic reviews and meta-analyses (PRISMA) flow diagram related to bibliographic searching and study selection.
See this image and copyright information in PMC

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