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Review
. 2021 Feb 4;13(2):508.
doi: 10.3390/nu13020508.

Impact of Parenteral Lipid Emulsion Components on Cholestatic Liver Disease in Neonates

Gregory Guthrie  1 , Douglas Burrin  1
Affiliations
Review

Impact of Parenteral Lipid Emulsion Components on Cholestatic Liver Disease in Neonates

Gregory Guthrie et al. Nutrients. .

Abstract

Total parenteral nutrition (TPN) is a life-saving intervention for infants that are unable to feed by mouth. Infants that remain on TPN for extended periods of time are at risk for the development of liver injury in the form of parenteral nutrition associated cholestasis (PNAC). Current research suggests the lipid component of TPN is a factor in the development of PNAC. Most notably, the fatty acid composition, vitamin E concentration, and presence of phytosterols are believed key mediators of lipid emulsion driven PNAC development. New emulsions comprised of fish oil and medium chain triglycerides show promise for reducing the incidence of PNAC in infants. In this review we will cover the current clinical studies on the benefit of fish oil and medium chain triglyceride containing lipid emulsions on the development of PNAC, the current constituents of lipid emulsions that may modulate the prevalence of PNAC, and potential new supplements to TPN to further reduce the incidence of PNAC.

Keywords: fish oil; lipid emulsions; medium chain triglycerides; olive oil; parenteral nutrition associated liver disease; preterm infants; soybean oil; vitamin E.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

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