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. 2021 Feb 4;9(2):167.
doi: 10.3390/healthcare9020167.

Proton Therapy for Mandibula Plate Phantom

Güler Burcu Senirkentli  1 , Fatih Ekinci  2 , Erkan Bostanci  3 , Mehmet Serdar Güzel  3 , Özlem Dağli  4 , Ahmed M Karim  5 , Alok Mishra  6   7
Affiliations

Proton Therapy for Mandibula Plate Phantom

Güler Burcu Senirkentli et al. Healthcare (Basel). .

Abstract

Purpose: In this study, the required dose rates for optimal treatment of tumoral tissues when using proton therapy in the treatment of defective tumours seen in mandibles has been calculated. We aimed to protect the surrounding soft and hard tissues from unnecessary radiation as well as to prevent complications of radiation. Bragg curves of therapeutic energized protons for two different mandible (molar and premolar) plate phantoms were computed and compared with similar calculations in the literature. The results were found to be within acceptable deviation values.

Methods: In this study, mandibular tooth plate phantoms were modelled for the molar and premolar areas and then a Monte Carlo simulation was used to calculate the Bragg curve, lateral straggle/range and recoil values of protons remaining in the therapeutic energy ranges. The mass and atomic densities of all the jawbone layers were selected and the effect of layer type and thickness on the Bragg curve, lateral straggle/range and the recoil were investigated. As protons move through different layers of density, lateral straggle and increases in the range were observed. A range of energies was used for the treatment of tumours at different depths in the mandible phantom.

Results: Simulations revealed that as the cortical bone thickness increased, Bragg peak position decreased between 0.47-3.3%. An increase in the number of layers results in a decrease in the Bragg peak position. Finally, as the proton energy increased, the amplitude of the second peak and its effect on Bragg peak position decreased.

Conclusion: These findings should guide the selection of appropriate energy levels in the treatment of tumour structures without damaging surrounding tissues.

Keywords: biomaterials; bragg peak; dental tumour; mandible plate phantom; paediatric dentistry; proton treatment.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
(a) A cross-sectional view of the focused mouth area (b) Mandibular region tooth plate premolar phantom section (c) Molar phantom section of mandibular region tooth plate. Layers (1–10) are explained in detail in Table 1.
Figure 2
Figure 2
Bragg curves formed by 41–44.9 MeV (a–d) energy protons in premolar plate phantom.
Figure 3
Figure 3
Bragg curves formed by 45–47.1 MeV (a,b) energy protons in premolar plate phantom.
Figure 4
Figure 4
Bragg curves formed by 89.8–93.7 MeV (a–d) energy protons in molar plate phantom.
Figure 5
Figure 5
Recoils curves of different energy proton beams in tooth plate molar (a) and premolar (b) phantoms.
Figure 6
Figure 6
Recoils curves of different energy proton beams in tooth plate molar phantoms. (a) Lateral straggle (b) Lateral range. Circles indicate lateral straggle and range for different energy levels.
Figure 7
Figure 7
Recoils curves of different energy proton beams in dental plate phantoms. (a) Lateral straggle (b) Lateral range. Circles indicate lateral straggle and range for different energy levels.
See this image and copyright information in PMC

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