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Review
. 2021 Feb 4;6(1):13.
doi: 10.3390/geriatrics6010013.

Pneumococcal Pneumonia and Invasive Pneumococcal Disease in Those 65 and Older: Rates of Detection, Risk Factors, Vaccine Effectiveness, Hospitalisation and Mortality

Roger E Thomas  1
Affiliations
Review

Pneumococcal Pneumonia and Invasive Pneumococcal Disease in Those 65 and Older: Rates of Detection, Risk Factors, Vaccine Effectiveness, Hospitalisation and Mortality

Roger E Thomas. Geriatrics (Basel). .

Abstract

Pneumococcal pneumonia (PP) and invasive pneumococcal disease (IPD) are important causes of morbidity and mortality in seniors worldwide. Incidence rates and serious outcomes worsen with increasing frailty, numbers of risk factors and decreasing immune competence with increasing age. Literature reviews in Medline and Embase were performed for pneumococcal disease incidence, risk factors, vaccination rates and effectiveness in the elderly. The introduction of protein-conjugated pneumoccal vaccines (PCV) for children markedly reduced IPD and PP in seniors, but serotypes not included in vaccines and with previously low levels increased. Pneumococcal polysaccharide (PPV23) vaccination does not change nasal and pharyngeal carriage rates. Pneumococcal and influenza vaccination rates in seniors are below guideline levels, especially in older seniors and nursing home staff. Pneumococcal and influenza carriage and vaccination rates of family members, nursing home health care workers and other contacts are unknown. National vaccination programmes are effective in increasing vaccination rates. Detection of IPD and PP initially depend on clinical symptoms and new chest X ray infiltrates and then varies according to the population and laboratory tests used. To understand how seniors and especially older seniors acquire PP and IPD data are needed on pneumococcal disease and carriage rates in family members, carers and contacts. Nursing homes need reconfiguring into small units with air ventilation externally from all rooms to minimise respiratory disease transmission and dedicated staff for each unit to minimise transmision of infectious diseaases.

Keywords: PCV and PPV23 pneumococcal vaccine effectiveness; detection methods for PP and IPD; invasive pneumococcal disease; mortality; nursing home redesign to minimise transmission; nursing home staff vaccination rates; pneumococcal nasal and pharyngeal carriages rates; pneumococcal pneumonia; risk factors for PP and IPD; seniors; vaccination effectiveness.

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Conflict of interest statement

The author declares no conflict of interest.

References

    1. Goldblatt D., O’Brien K.L. Pneumococcal Infections. Chapter 141 (pages 1–20) In: Jameson L.J., Fauci A.S., Kasper D.L., Hauser S.L., Longo D.L., Loscalzo J., editors. Harrison’s Principles of Internal Medicine. 20th ed. McGraw-Hill Education; New York, NY, USA: 2018. p. 8.
    1. Goldblatt D., O’Brien K.L. Pneumococcal Infections. Chapter 141 (pages 1–20) In: Jameson L.J., Fauci A.S., Kasper D.L., Hauser S.L., Longo D.L., Loscalzo J., editors. Harrison’s Principles of Internal Medicine. 20th ed. McGraw-Hill Education; New York, NY, USA: 2018. p. 2.
    1. Goldblatt D., O’Brien K.L. Pneumococcal Infections. Chapter 141 (pages 1–20) In: Jameson L.J., Fauci A.S., Kasper D.L., Hauser S.L., Longo D.L., Loscalzo J., editors. Harrison’s Principles of Internal Medicine. 20th ed. McGraw-Hill Education; New York, NY, USA: 2018. p. 4.
    1. Goldblatt D., O’Brien K.L. Pneumococcal Infections. Chapter 141 (pages 1–20) In: Jameson L.J., Fauci A.S., Kasper D.L., Hauser S.L., Longo D.L., Loscalzo J., editors. Harrison’s Principles of Internal Medicine. 20th ed. McGraw-Hill Education; New York, NY, USA: 2018. p. 6.
    1. Goldblatt D., O’Brien K.L. Pneumococcal Infections. Chapter 141 (pages 1–20) In: Jameson L.J., Fauci A.S., Kasper D.L., Hauser S.L., Longo D.L., Loscalzo J., editors. Harrison’s Principles of Internal Medicine. 20th ed. McGraw-Hill Education; New York, NY, USA: 2018. p. 7.

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