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. 2021 Apr;124(9):1475-1477.
doi: 10.1038/s41416-020-01223-7. Epub 2021 Feb 9.

Transforming the landscape of early cancer detection using blood tests-Commentary on current methodologies and future prospects

Affiliations

Transforming the landscape of early cancer detection using blood tests-Commentary on current methodologies and future prospects

Minetta C Liu. Br J Cancer. 2021 Apr.

Abstract

Early cancer detection should lead to an overall stage shift, less-intensive treatments and better patient outcomes. Current recommended screening programmes are limited to a handful of individual cancers. A multi-cancer early detection test that simultaneously detects and localises multiple cancers could reduce the morbidity and mortality associated with cancer.

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Conflict of interest statement

The Mayo Clinic was compensated for M.C.L.’s advisory board activities for GRAIL, Inc.

Figures

Fig. 1
Fig. 1. Attributes of multi-cancer detection methods.
MCED multi-cancer early detection, TOO tumour of origin.

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References

    1. Liu MC, Oxnard GR, Klein EA, Swanton C, Seiden MV, CCGA Consortium. Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA. Ann. Oncol. 2020;31:745–759. doi: 10.1016/j.annonc.2020.02.011. - DOI - PMC - PubMed
    1. Lennon AM, Buchanan AH, Kinde I, Warren A, Honushefsky A, Cohain AT, et al. Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention. Science. 2020;369:eabb9601. doi: 10.1126/science.abb9601. - DOI - PMC - PubMed
    1. Ahlquist DA. Universal cancer screening: revolutionary, rational, and realizable. npj Precis. Oncol. 2018;2:23. doi: 10.1038/s41698-018-0066-x. - DOI - PMC - PubMed
    1. Cescon DW, Bratman SV, Chan SM, Siu LL. Circulating tumor DNA and liquid biopsy in oncology. Nat. Cancer. 2020;1:276–290. doi: 10.1038/s43018-020-0043-5. - DOI - PubMed
    1. Chen X, Gole J, Gore A, He Q, Lu M, Min J, et al. Non-invasive early detection of cancer four years before conventional diagnosis using a blood test. Nat. Commun. 2020;11:3475. doi: 10.1038/s41467-020-17316-z. - DOI - PMC - PubMed

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