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. 2021 Apr;71(4):261-266.
doi: 10.1111/pin.13074. Epub 2021 Feb 9.

Tissue factor expression and tumor-infiltrating T lymphocytes in ovarian carcinomas and their association with venous thromboembolism

Toshihiro Gi  1 , Atsushi Yamashita  1 , Murasaki Aman  2 , Aya Kuwahara  1   3 , Yujiro Asada  1 , Yasuyuki Kawagoe  4 , Junji Onishi  4 , Hiroshi Sameshima  4 , Yuichiro Sato  2
Affiliations

Tissue factor expression and tumor-infiltrating T lymphocytes in ovarian carcinomas and their association with venous thromboembolism

Toshihiro Gi et al. Pathol Int. 2021 Apr.

Abstract

Ovarian cancer is a known risk factor of venous thromboembolism (VTE). Thrombogenic factor expression and lymphocytic infiltrate have been reported in endometriosis and ovarian cancers. We reviewed 30 cases of ovarian carcinomas (high grade serous carcinoma, 10; endometrioid carcinoma, 10; clear cell carcinoma (CCC), 10) and 16 endometriotic lesions. We immunohistochemically investigated the expressions of tissue factor (TF), podoplanin, P-selectin, and number of CD4 and CD8 positive lymphocytes in cancer tissue and endometriotic lesions, along with their relationship with VTE. The expression of TF was higher in CCC. The TF expression and the number of CD8 positive cells were higher in cancer tissues with VTE than in those without VTE. The podoplanin or P-selectin expression did not differ among histological types or between cases with and without VTE. Our results demonstrated a high TF expression and intraepithelial CD8 cells in CCC, which were associated with VTE. The results suggest that infiltrating lymphocytes may affect TF expression that, in turn, influences VTE.

Keywords: P-selectin; cancer-associated thrombosis; ovarian cancer; pathology; podoplanin; tissue factor; tumor-infiltrating lymphocyte; venous thromboembolism.

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References

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