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Review
. 2020 Dec 30;91(14-S):e2020005.
doi: 10.23750/abm.v91i14-S.10785.

Distrectual osteosarcopenia in limb disuse: case report and mini literature review

Gabriele Filoni  1 , Michele Di Lonardo  2 , Giovanni Mandile  3 , Lorenzo Andreani  4 , Francesca Falossi  5 , Alessandro Franchi  6 , Vanna Bottai  7 , Rodolfo Capanna  8
Affiliations
Review

Distrectual osteosarcopenia in limb disuse: case report and mini literature review

Gabriele Filoni et al. Acta Biomed. .

Abstract

Osteosarcopenia is a new concept of association of osteoporosis and sarcopenia. Both of these pathologies are more frequent in old people and general affects all the skeleton with increased risk of falls and fractures, loss of global function, fragility, and mortality, but also surgical failures. The coexistence of these condition derives from a close relationship, not only anatomical, between bone and muscle tissues. Sometimes these pathological conditions can involve only a skeleton segment, due to local disuse, causing a district form of sarcopenia. In this clinical case, Authors describes a case of isolated lower limb osteosarcopenia in a young non-osteoporotic patient, due to a prolonged limb disuse, complicated by surgical treatment failure for previous pathology, diagnosed by clinical, laboratory, instrumental and histopathological exams.

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Conflict of interest statement

Each author declares that he or she has no commercial associations (e.g. consultancies, stock ownership, equity interest, patent/licensing arrangement etc.) that might pose a conflict of interest in connection with the submitted article.

Figures

Figure 1.
Figure 1.
Implant Failure X-Ray
Figure 2.
Figure 2.
DXA exam (from left to right: spine, left femur, right femur, DXA values)
Figure 3.
Figure 3.
Presence of fibro-adipose stripes and a partial muscle atrophy in the limb affected by disuse (A: Left Femur, B: Right Femur)
See this image and copyright information in PMC

References

    1. Hirschfeld H. P, Kinsella R, Duque G. Osteosarcopenia: where bone, muscle, and fat collide, Osteoporos. Int. J. Establ. Result Coop. Eur. Found. Osteoporos. Natl. Osteoporos. Found. USA. 2017;28(10):2781–2790. doi: 10.1007/s00198-017-4151-8. - PubMed
    1. Beaudart C, et al. Sarcopenia in daily practice: assessment and management. BMC Geriatr. dic. 2016;16(1):170. doi: 10.1186/s12877-016-0349-4. - PMC - PubMed
    1. Kanis J. A, Cooper C, Rizzoli R, J.-Y Reginster. Scientific Advisory Board of the European Society for Clinical and Economic Aspects of Osteoporosis (ESCEO) and the Committees of Scientific Advisors and National Societies of the International Osteoporosis Foundation (IOF), European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos. Int. J. Establ. Result Coop. Eur. Found. Osteoporos. Natl. Osteoporos. Found. USA. gen. 2019;30(1):3–44. doi: 10.1007/s00198-018-4704-5. - PMC - PubMed
    1. Okamura H, et al. Risk factors predicting osteosarcopenia in postmenopausal women with osteoporosis: A retrospective study. PLOS ONE. ago. 2020;15:e0237454. doi: 10.1371/journal.pone.0237454. - PMC - PubMed
    1. Fricke O, Schoenau E. The ‘Functional Muscle-Bone Unit’: Probing the relevance of mechanical signals for bone development in children and adolescents. Growth Horm. IGF Res. feb. 2007;17(1):1–9. doi: 10.1016/j.ghir.2006.10.004. - PubMed