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Editorial
. 2021 Mar 1;42(9):934-937.
doi: 10.1093/eurheartj/ehaa1089.

Unfolding and disentangling coronary vascular disease through genome-wide association studies

Jeanette Erdmann  1   2   3 , Sander W van der Laan  4
Affiliations
Editorial

Unfolding and disentangling coronary vascular disease through genome-wide association studies

Jeanette Erdmann et al. Eur Heart J. .
No abstract available

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Figures

Figure 1
Figure 1
Over 160 risk loci for CAD and MI have been identified by GWAS. Roughly half of them are functionally known to act in pathways involved in the process of atherosclerosis and its sequela MI. Atherosclerosis is a progressive disease starting early in life, and genetic variants as well as risk factors, such as high cholesterol, smoking, no sports, hypertension, and diabetes, affect throughout a person’s lifetime the susceptibility to the initiation, progression, and the final outcome of atherosclerosis. Created with BioRender.com.
See this image and copyright information in PMC

Comment on

  • Genome-wide analysis identifies novel susceptibility loci for myocardial infarction.
    Hartiala JA, Han Y, Jia Q, Hilser JR, Huang P, Gukasyan J, Schwartzman WS, Cai Z, Biswas S, Trégouët DA, Smith NL; INVENT Consortium; CHARGE Consortium Hemostasis Working Group; GENIUS-CHD Consortium; Seldin M, Pan C, Mehrabian M, Lusis AJ, Bazeley P, Sun YV, Liu C, Quyyumi AA, Scholz M, Thiery J, Delgado GE, Kleber ME, März W, Howe LJ, Asselbergs FW, van Vugt M, Vlachojannis GJ, Patel RS, Lyytikäinen LP, Kähönen M, Lehtimäki T, Nieminen TVM, Kuukasjärvi P, Laurikka JO, Chang X, Heng CK, Jiang R, Kraus WE, Hauser ER, Ferguson JF, Reilly MP, Ito K, Koyama S, Kamatani Y, Komuro I; Biobank Japan; Stolze LK, Romanoski CE, Khan MD, Turner AW, Miller CL, Aherrahrou R, Civelek M, Ma L, Björkegren JLM, Kumar SR, Tang WHW, Hazen SL, Allayee H. Hartiala JA, et al. Eur Heart J. 2021 Mar 1;42(9):919-933. doi: 10.1093/eurheartj/ehaa1040. Eur Heart J. 2021. PMID: 33532862 Free PMC article.

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