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Comment
. 2021 Feb 8;39(2):145-147.
doi: 10.1016/j.ccell.2021.01.015.

Not All Tumor-Infiltrating CD8+ T Cells Are Created Equal

Werner Held  1 , Daniel E Speiser  2
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Not All Tumor-Infiltrating CD8+ T Cells Are Created Equal

Werner Held et al. Cancer Cell. .
Free article

Abstract

Adoptive cell immunotherapy using in vitro expanded autologous tumor-infiltrating lymphocytes has the potential to mediate durable remission of certain types of cancer. A recent paper in Science shows that complete and durable control of metastatic melanoma requires the infusion of tumor-specific CD8+ T cells that have stem-cell-like properties.

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Conflict of interest statement

Declaration of Interests The authors declare no competing interests.

Comment on

  • Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer.
    Krishna S, Lowery FJ, Copeland AR, Bahadiroglu E, Mukherjee R, Jia L, Anibal JT, Sachs A, Adebola SO, Gurusamy D, Yu Z, Hill V, Gartner JJ, Li YF, Parkhurst M, Paria B, Kvistborg P, Kelly MC, Goff SL, Altan-Bonnet G, Robbins PF, Rosenberg SA. Krishna S, et al. Science. 2020 Dec 11;370(6522):1328-1334. doi: 10.1126/science.abb9847. Science. 2020. PMID: 33303615 Free PMC article.

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