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Comment
. 2021 Feb 8;56(3):251-252.
doi: 10.1016/j.devcel.2021.01.007.

How NPC1 Loss Twists the TORCque of Lysosomes

W Mike Henne  1
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How NPC1 Loss Twists the TORCque of Lysosomes

W Mike Henne. Dev Cell. .
Free article

Abstract

Niemann-Pick type C is a neurological disorder caused by mutations in the lysosome cholesterol exporter NPC1. In this issue of Developmental Cell, Davis et al. dissect how NPC1 loss elevates mTORC1 signaling, and demonstrate that suppression of mTORC1 signaling can rescue disease pathology in NPC1-deficient cell models.

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Declaration of Interests The authors declare no competing interests.

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