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Comment
. 2021 Feb 8;56(3):255-256.
doi: 10.1016/j.devcel.2021.01.008.

Stop the Divide and Build Coronary Arteries

G Zarkada  1 , A Eichmann  2
Affiliations
Comment

Stop the Divide and Build Coronary Arteries

G Zarkada et al. Dev Cell. .

Abstract

Understanding how arteries develop is critical to design repair strategies for coronary artery disease and treatment of arteriovenous malformations. Luo et al. report in Nature that NOTCH drives coronary artery formation by suppressing MYC, a transcription factor involved in cell cycle progression and cell metabolism.

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Conflict of interest statement

Declaration of Interests The authors declare no competing interests.

Figures

Figure 1
Figure 1. Proposed Mechanism of Coronary Artery Formation
Proposed mechanism of coronary artery formation. Arterial fate is predetermined prior to the onset of blood flow, in pre-arterial cells with high VEGF and NOTCH signaling. NOTCH signaling suppresses the expression or MYC and MYC-target genes, allowing ECs to adopt a transcriptional arterial signature and form coronary arteries.
See this image and copyright information in PMC

Comment on

  • Arterialization requires the timely suppression of cell growth.
    Luo W, Garcia-Gonzalez I, Fernández-Chacón M, Casquero-Garcia V, Sanchez-Muñoz MS, Mühleder S, Garcia-Ortega L, Andrade J, Potente M, Benedito R. Luo W, et al. Nature. 2021 Jan;589(7842):437-441. doi: 10.1038/s41586-020-3018-x. Epub 2020 Dec 9. Nature. 2021. PMID: 33299176 Free PMC article.

References

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