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. 2021 Feb 10;59(8):1336-1352.
doi: 10.1515/cclm-2020-1734. Print 2021 Jul 27.

The impact of interventions applied in primary care to optimize the use of laboratory tests: a systematic review

Serena Lillo  1   2 , Trine Rennebod Larsen  1   2 , Leif Pennerup  1 , Steen Antonsen  1
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Free article

The impact of interventions applied in primary care to optimize the use of laboratory tests: a systematic review

Serena Lillo et al. Clin Chem Lab Med. .
Free article

Abstract

Laboratory tests are important tools in primary care, but their use is sometimes inappropriate. The aim of this review is to give an overview of interventions applied in primary care to optimize the use of laboratory tests. A search for studies was made in the MEDLINE and EMBASE databases. We also extracted studies from two previous reviews published in 2015. Studies were included if they described application of an intervention aiming to optimize the use of laboratory tests. We also evaluated the overall risk of bias of the studies. We included 24 studies. The interventions were categorized as: education, feedback reports and computerized physician order entry (CPOE) strategies. Most of the studies were classified as medium or high risk of bias while only three studies were evaluated as low risk of bias. The majority of the studies aimed at reducing the number of tests, while four studies investigated interventions aiming to increase the use of specific tests. Despite the studies being heterogeneous, we made results comparable by transforming the results into weighted relative changes in number of tests when necessary. Education changed the number of tests consistently, and these results were supported by the low risk of bias of the papers. Feedback reports have mainly been applied in combination with education, while when used alone the effect was minimal. The use of CPOE strategies seem to produce a marked change in the number of test requests, however the studies were of medium or high risk of bias.

Keywords: interventions; laboratory tests; primary care and optimization.

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