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Review
. 2021 Feb 7;10(4):630.
doi: 10.3390/jcm10040630.

Thinking outside the Ischemia Box: Advancements in the Use of Multiple Sclerosis Drugs in Ischemic Stroke

Athina-Maria Aloizou  1 , Vasileios Siokas  1 , Georgia Pateraki  1 , Ioannis Liampas  1 , Christos Bakirtzis  2 , Zisis Tsouris  1 , George Lazopoulos  3 , Daniela Calina  4 , Anca Oana Docea  5 , Aristidis Tsatsakis  6 , Dimitrios P Bogdanos  7 , Efthimios Dardiotis  1
Affiliations
Review

Thinking outside the Ischemia Box: Advancements in the Use of Multiple Sclerosis Drugs in Ischemic Stroke

Athina-Maria Aloizou et al. J Clin Med. .

Abstract

Ischemic stroke (IS) is a major cause of death and disability, despite early intervention. Thrombo-inflammation, the inflammatory process triggered by ischemia, is a concept that ties IS with multiple sclerosis (MS), under the wider 'umbrella' of neuroinflammation, i.e., the inflammation of the nervous tissue. Drawing from this, numerous studies have explored the potential of MS disease-modifying drugs in the setting of IS. In this review, we present the available studies and discuss their potential in ameliorating IS outcomes. Based on our search, the vast majority of the studies have been conducted on animals, yielding mostly positive results. Two clinical trials involving natalizumab showed that it does not confer any benefits, but four human studies regarding fingolimod have showcased its potential in improving recovery prospects. However, concerns on safety and other issues are raised, and basic questions still need to be answered.

Keywords: fingolimod; ischemic stroke; multiple sclerosis; natalizumab.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flowchart for the search algorithm’s results.
Figure 2
Figure 2
Neuroinflammation, the overlap between Multiple Sclerosis (MS) and Ischemic Stroke (IS) gives way to the application of MS-disease-modifying drugs to be applied in cerebral ischemia.
See this image and copyright information in PMC

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