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Meta-Analysis
. 2021 Jan-Dec:20:1533033821989822.
doi: 10.1177/1533033821989822.

Prognostic Value of Pretreatment D-Dimer Level in Small-Cell Lung Cancer: A Meta-Analysis

Jialong Li  1 , Yan Wang  1 , Jue Li  1 , Guowei Che  1
Affiliations
Meta-Analysis

Prognostic Value of Pretreatment D-Dimer Level in Small-Cell Lung Cancer: A Meta-Analysis

Jialong Li et al. Technol Cancer Res Treat. 2021 Jan-Dec.

Abstract

Purpose: Pretreatment plasma d-dimer has been reported to be a potential prognostic indicator of lung cancer. To determine the prognostic significance of pretreatment d-dimer level in predicting clinical outcomes, such as the overall survival (OS) and progression-free survival (PFS), of patients with small cell lung cancer (SCLC).

Methods: A systematic search in PubMed, Web of Science, EMBASE, Cochrane Library, CNKI, SinoMed, Wanfang and VIP databases was performed to identify available studies. The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were applied to assess the association of pretreatment d-dimer level with prognosis of SCLC patients. All statistical analyses were conducted via the STATA 12.0 version software.

Results: A total of 7 studies involving 964 patients were included in this meta-analysis and all patients were from China. The results showed that elevated pretreatment d-dimer level was significantly correlated with worse OS (HR = 1.90, 95% CI: 1.55-2.34, P < 0.001) and PFS (HR = 1.52, 95% CI: 1.24-1.85, P<0.001). Subgroup analyses based on the treatment, d-dimer cut-off, detection method and source of HR were also performed to further verify the prognostic value of pretreatment d-dimer level in SCLC.

Conclusions: Pretreatment blood concentration of d-dimer may deserve as a reliable factor to predict prognosis of Chinese patients with SCLC. More well-designed prospective studies with large samples are still needed to verify our findings.

Keywords: d-dimer; meta-analysis; prognosis; small cell lung cancer.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Flow diagram of the literature review.
Figure 2.
Figure 2.
Forest plot of the association between pretreatment d-dimer level and overall survival. HR: hazard ratio; CI: confidence interval.
Figure 3.
Figure 3.
Forest plot of the association between pretreatment d-dimer and progression-free survival. HR: hazard ratio; CI: confidence interval.
Figure 4.
Figure 4.
Sensitivity analysis of the association between pretreatment d-dimer and overall survival.
See this image and copyright information in PMC

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