Sensory Nerves Regulate Transcriptional Dynamics of Lymph Node Cells
- PMID: 33563563
- DOI: 10.1016/j.it.2021.01.008
Sensory Nerves Regulate Transcriptional Dynamics of Lymph Node Cells
Abstract
The nervous system plays important roles in homeostasis and inflammatory responses in tissues. However, the regulation of lymph nodes (LN) by nerves remains largely unknown. Huang et al. demonstrate that LNs are innervated by unique peptidergic nociceptors that signal to various endothelial, stromal, and immune cell types in LNs.
Copyright © 2021 Elsevier Ltd. All rights reserved.
Conflict of interest statement
Declaration of Interests No interests are declared.
Comment on
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Lymph nodes are innervated by a unique population of sensory neurons with immunomodulatory potential.Cell. 2021 Jan 21;184(2):441-459.e25. doi: 10.1016/j.cell.2020.11.028. Epub 2020 Dec 16. Cell. 2021. PMID: 33333021 Free PMC article.
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