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Comment
. 2021 Mar;42(3):180-182.
doi: 10.1016/j.it.2021.01.008. Epub 2021 Feb 6.

Sensory Nerves Regulate Transcriptional Dynamics of Lymph Node Cells

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Sensory Nerves Regulate Transcriptional Dynamics of Lymph Node Cells

Peter L Wang et al. Trends Immunol. 2021 Mar.

Abstract

The nervous system plays important roles in homeostasis and inflammatory responses in tissues. However, the regulation of lymph nodes (LN) by nerves remains largely unknown. Huang et al. demonstrate that LNs are innervated by unique peptidergic nociceptors that signal to various endothelial, stromal, and immune cell types in LNs.

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Declaration of Interests No interests are declared.

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