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Clinical Trial
. 1988 Mar;29(3):279-83.
doi: 10.1136/gut.29.3.279.

Effect of treatment on Campylobacter pylori in peptic disease: a randomised prospective trial

H Humphreys  1 , S Bourke, C Dooley, D McKenna, B Power, C T Keane, E C Sweeney, C O'Moráin
Affiliations
Clinical Trial

Effect of treatment on Campylobacter pylori in peptic disease: a randomised prospective trial

H Humphreys et al. Gut. 1988 Mar.

Abstract

This study investigated the effect of colloidal bismuth subcitrate and cimetidine on Campylobacter pylori in peptic disease. In 74% of 135 patients with peptic disease diagnosed at endoscopy C pylori was detected before treatment. Compared with cimetidine, colloidal bismuth subcitrate significantly decreased the incidence of C pylori after six weeks of treatment (p less than 0.001). In the colloidal bismuth subcitrate group, subsequent healing of the lesion was correlated with the clearance of C pylori, unlike in the cimetidine group. C pylori was strongly associated with the presence of histological gastritis, which was decreased by colloidal bismuth subcitrate (p less than 0.001).

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