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. 2020 May 25;14(1):442-444.
doi: 10.1093/ckj/sfaa068. eCollection 2021 Jan.

Is stiripentol truly effective for treating primary hyperoxaluria?

Cristina Martin-Higueras  1   2 , Markus Feldkötter  3 , Bernd Hoppe  2
Affiliations

Is stiripentol truly effective for treating primary hyperoxaluria?

Cristina Martin-Higueras et al. Clin Kidney J. .
No abstract available

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Figures

FIGURE 1
FIGURE 1
Response of Patient 1 (AGXT: c.33dupC/c.525-1G>A) to stiripentol. (A) Ultrasound with twinkling sign of the bilateral prevesical stones and follow-up of (B) serum creatinine (in mg/dL), (C) Pox (µmol/L) and (D) Uox (expressed as the molar oxalate:creatinine ratio in mmol/mol and as oxalate excretion in mmol/1.73 m2/day) since diagnosis and during stiripentol treatment.
FIGURE 2
FIGURE 2
Response of Patient 2 (AGXT: 508 G>A homozygous) to stiripentol. (A) Ultrasound at the time of diagnosis, showing hyperechogenic kidney with generalized nephrocalcinosis. Follow-up of (B) Pox levels before (black) and after (pink) haemodialysis, as well as (C) stiripentol dosage (mg/kg) and blood levels (mg/L) in a PHI patient with infantile oxalosis and dialysis treatment.
See this image and copyright information in PMC

References

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    1. Wyatt CM, Drüeke TB.. Stiripentol for the treatment of primary hyperoxaluria and calcium oxalate nephropathy. Kidney Int 2020;97:17–19. - PubMed
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    1. Hoppe B, Cochat P, Lemoine S. et al. PHYOX: a safety and tolerability study of DCR-PHXC in primary hyperoxaluria types 1 and 2. Poster TH-PO449. Presented at the American Society of Nephrology Kidney Week 2019, Washington, DC.