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Case Reports
. 2021 Jan 5;13(1):e12502.
doi: 10.7759/cureus.12502.

Atorvastatin-Induced Refractory Thrombocytopenia

Jasmine Ghuman  1 , Nicholas T Manasewitsch  1 , Joban Ghuman  2 , Daniel Antwi-Amoabeng  1 , Gurpreet Chahal  1
Affiliations
Case Reports

Atorvastatin-Induced Refractory Thrombocytopenia

Jasmine Ghuman et al. Cureus. .

Abstract

Drug-induced thrombocytopenia is rarely associated with statin medications. We describe the case of a 69-year-old woman who developed refractory thrombocytopenia following atorvastatin use. To our knowledge, this is the fourth reported case of atorvastatin-induced thrombocytopenia and the first reported case of atorvastatin-induced refractory thrombocytopenia. Additionally, we summarize the cases of statin-induced thrombocytopenia reported in the medical literature.

Keywords: atorvastatin; drug reaction; drug-induced thrombocytopenia; hyperlipidemia; petechiae; platelet; purpura; refractory; statin-induced; thrombocytopenia.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Temporal variations in platelet count after initiation of atorvastatin and response to interventions.
IVIG- Intravenous mmunoglobulin
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References

    1. Primary and secondary prevention of acute coronary syndromes: the role of the statins. Diamantis E, Troupis T, Mazarakis A, Kyriakos G, Diamanti S, Troupis G, Skandalakis P. Recent Adv Cardiovasc Drug Discov. 2014;9:97–105. - PubMed
    1. Statins in stroke. Aznaouridis K, Masoura C, Vlachopoulous C, Tousoulis D. Curr Med Chem. 2019;26:6174–6185. - PubMed
    1. Atorvastatin: its clinical role in cerebrovascular prevention. Gaspardone A, Area M. Drugs. 2007;67:55–62. - PubMed
    1. An overview of the clinical safety profile of atorvastatin (lipitor), a new HMG-CoA reductase inhibitor. Black DM, Bakker-Arkema RB, Nawrocki JW. Arch Intern Med. 1998;158:577–584. - PubMed
    1. Prediction of pharmacokinetic drug-drug interactions causing atorvastatin-induced rhabdomyolysis using physiologically based pharmacokinetic modelling. Li S, Yu Y, Jin Z, et al. Biomed Pharmacother. 2019;119:109416. - PubMed

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