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Case Reports
. 2021 Jan 6;13(1):e12530.
doi: 10.7759/cureus.12530.

Alarming Eosinophilia From Dobutamine Infusion

Naji Maaliki  1 , Aleem A Ali  1 , Christopher Izzo  1 , Hamel Patel  1 , Steve Antoine  2
Affiliations
Case Reports

Alarming Eosinophilia From Dobutamine Infusion

Naji Maaliki et al. Cureus. .

Abstract

A 49-year-old male with a history of nonischemic heart failure with reduced ejection fraction, hypertension, diabetes was admitted for cardiogenic shock. Treatment started with a high dose of dobutamine infusion. While the patient's volume status improved, his clinical status declined as he became febrile and hypotensive. He was found to have severe dobutamine-induced eosinophilia, corrected only upon dobutamine cessation and steroid administration. A comprehensive investigation ruled out other potential etiologies. Peripheral eosinophilia is a rare adverse effect associated with dobutamine, leading to a significant deterioration in already decompensated patients.

Keywords: cardiogenic shock; critical care cardiology; dobutamine; drug-induced eosinophilia; eosinophila; heart failure; hyper-eosinophilia syndrome.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Chest X-ray demonstrating bilateral pulmonary edema and cardiomegaly supportive of heart failure.
Figure 2
Figure 2. Eosinophil percentage and WBC increase during dobutamine infusion (stopped after day 8).
WBC: white blood cell count.
See this image and copyright information in PMC

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