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Review
. 2021 May;115(5):860-869.
doi: 10.1111/mmi.14642. Epub 2021 Feb 9.

Interaction between transforming Theileria parasites and their host bovine leukocytes

Shahin Tajeri  1   2 , Malak Haidar  1   3   4 , Takaya Sakura  1   5   6 , Gordon Langsley  1
Affiliations
Free article
Review

Interaction between transforming Theileria parasites and their host bovine leukocytes

Shahin Tajeri et al. Mol Microbiol. 2021 May.
Free article

Abstract

Theileria are tick-transmitted parasites that cause often fatal leuko-proliferative diseases in cattle called tropical theileriosis (T. annulata) and East Coast fever (T. parva). However, upon treatment with anti-theilerial drug-transformed leukocytes die of apoptosis indicating that Theileria-induced transformation is reversible making infected leukocytes a powerful example of how intracellular parasites interact with their hosts. Theileria-transformed leukocytes disseminate throughout infected cattle causing a cancer-like disease and here, we discuss how cytokines, noncoding RNAs and oncometabolites can contribute to the transformed phenotype and disease pathology.

Keywords: Theileria; cytokines; dissemination; miRNA; oncometabolite; transformation.

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References

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