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Review
. 2021 Apr 20;16(8):1226-1233.
doi: 10.1002/cmdc.202000940. Epub 2021 Feb 10.

Helical Antimicrobial Peptide Foldamers Containing Non-proteinogenic Amino Acids

Hidetomo Yokoo  1 , Motoharu Hirano  1   2 , Takashi Misawa  1 , Yosuke Demizu  1   2
Affiliations
Review

Helical Antimicrobial Peptide Foldamers Containing Non-proteinogenic Amino Acids

Hidetomo Yokoo et al. ChemMedChem. .

Abstract

Antimicrobial peptides (AMPs) are potential novel therapeutic drugs against microbial infections. Most AMPs function by disrupting microbial membranes because of their amphipathic properties and ordered secondary structures. In this minireview, we describe recent efforts to develop helical AMP foldamers containing non-proteinogenic amino acids, such as α,α-disubstituted α-amino acids, β-amino acids, γ-amino acids, side-chain stapling and N-alkyl glycines.

Keywords: Gram-negative bacteria; Gram-positive bacteria; antimicrobial peptides; foldamers; helixes; non-proteinogenic amino acids.

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