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. 2021 Feb 10;32(5):513-530.
doi: 10.1515/revneuro-2020-0148. Print 2021 Jul 27.

Current updates on various treatment approaches in the early management of acute spinal cord injury

Brian Fiani  1 , Mohammad Arsal Arshad  1 , Emad Salman Shaikh  2 , Aqsa Baig  3 , Mudassir Farooqui  4 , Muhammed Abubakar Ayub  5 , Atif Zafar  4 , Syed A Quadri  5
Affiliations

Current updates on various treatment approaches in the early management of acute spinal cord injury

Brian Fiani et al. Rev Neurosci. .

Abstract

Spinal cord injury (SCI) is a debilitating condition which often leads to a severe disability and ultimately impact patient's physical, psychological, and social well-being. The management of acute SCI has evolved over the couple of decades due to improved understanding of injury mechanisms and increasing knowledge of disease. Currently, the early management of acute SCI patient includes pharmacological agents, surgical intervention and newly experimental neuroprotective strategies. However, many controversial areas are still surrounding in the current treatment strategies for acute SCI, including the optimal timing of surgical intervention, early versus delayed decompression outcome benefits, the use of methylprednisolone. Due to the lack of consensus, the optimal standard of care has been varied across treatment centres. The authors have shed a light on the current updates on early treatment approaches and neuroprotective strategies in the initial management of acute SCI in order to protect the early neurologic injury and reduce the future disability.

Keywords: spinal cord; spinal cord injury; spine; trauma.

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References

    1. Aarabi, B., Walters, B.C., Dhall, S.S., Gelb, D.E., Hurlbert, R.J., Rozzelle, C.J., Ryken, T.C., Theodore, N., and Hadley, M.N. (2013). Subaxial cervical spine injury classification systems. Neurosurgery 72(Suppl 2): 170–186.
    1. Anderson, L.D. and D’Alonzo, R.T. (2004). Fractures of the odontoid process of the axis. 1974. J. Bone. Jt. Surg. Am. 86: 2081.
    1. Azbill, R.D., Mu, X., and Springer, J.E. (2000). Riluzole increases high-affinity glutamate uptake in rat spinal cord synaptosomes. Brain Res. 871: 175–180.
    1. Batchelor, P.E., Wills, T.E., Skeers, P., Battistuzzo, C.R., Macleod, M.R., Howells, D.W., and Sena, E.S. (2013). Meta-analysis of pre-clinical studies of early decompression in acute spinal cord injury: a battle of time and pressure. PLoS One 8: e72659.
    1. Bracken, M.B. (2012). Steroids for acute spinal cord injury. Cochrane Database Syst. Rev. 1, CD001046.

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