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Review
. 2021 Jul-Aug;47(4):747-752.
doi: 10.1590/S1677-5538.IBJU.2021.99.06.

Otorhinolaryngological adverse effects of urological drugs

Nathalia de Paula Doyle Maia  1 , Karen de Carvalho Lopes  2 , Fernando Freitas Ganança  2
Affiliations
Review

Otorhinolaryngological adverse effects of urological drugs

Nathalia de Paula Doyle Maia et al. Int Braz J Urol. 2021 Jul-Aug.

Abstract

Purpose: To describe the otorhinolaryngological adverse effects of the main drugs used in urological practice.

Materials and methods: A review of the scientific literature was performed using a combination of specific descriptors (side effect, adverse effect, scopolamine, sildenafil, tadalafil, vardenafil, oxybutynin, tolterodine, spironolactone, furosemide, hydrochlorothiazide, doxazosin, alfuzosin, terazosin, prazosin, tamsulosin, desmopressin) contained in publications until April 2020. Manuscripts written in English, Portuguese, and Spanish were manually selected from the title and abstract. The main drugs used in Urology were divided into five groups to describe their possible adverse effects: alpha-blockers, anticholinergics, diuretics, hormones, and phosphodiesterase inhibitors.

Results: The main drugs used in Urology may cause several otorhinolaryngological adverse effects. Dizziness was most common, but dry mouth, rhinitis, nasal congestion, epistaxis, hearing loss, tinnitus, and rhinorrhea were also reported and varies among drug classes.

Conclusions: Most of the drugs used in urological practice have otorhinolaryngological adverse effects. Dizziness was most common, but dry mouth, rhinitis, nasal congestion, epistaxis, hearing loss, tinnitus, and rhinorrhea were also reported. Therefore, doctors must be aware of these adverse effects to improve adherence to the treatment and to minimize damage to the health of patients.

Keywords: Adrenergic alpha-1 Receptor Antagonists; Cholinergic Antagonists; Deamino Arginine Vasopressin.

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Conflict of interest statement

None declared.

References

    1. 1. Farokhzad OC, Dimitrakov JD, Karp JM, Khademhosseini A, Freeman MR, Langer R. Drug delivery systems in urology--getting “smarter”. Urology. 2006; 68:463-9. - PMC - PubMed
    1. 2. Eardley I, Whelan P, Kirby R, Schaeffer A. Drug treatment in urology: John Wiley & Sons; 2008; p. x.
    1. 3. Djavan B, Marberger M. A meta-analysis on the efficacy and tolerability of alpha1-adrenoceptor antagonists in patients with lower urinary tract symptoms suggestive of benign prostatic obstruction. Eur Urol. 1999; 36:1-13. - PubMed
    1. 4. Taylor SH. Pharmacotherapeutic stature of doxazosin and its role in coronary risk reduction. Am Heart J. 1988; 116(6 Pt 2):1735-47. - PubMed
    1. 5. Roehrborn CG, Schwinn DA. Alpha1-adrenergic receptors and their inhibitors in lower urinary tract symptoms and benign prostatic hyperplasia. J Urol. 2004; 171:1029-35. - PubMed