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Comparative Study
. 2021 Feb 10;16(2):e0246890.
doi: 10.1371/journal.pone.0246890. eCollection 2021.

Comparisons of fatigue between dialysis modalities: A cross-sectional study

Yukio Maruyama  1 , Masaaki Nakayama  2 , Atsushi Ueda  3 , Mariko Miyazaki  4 , Takashi Yokoo  1
Affiliations
Comparative Study

Comparisons of fatigue between dialysis modalities: A cross-sectional study

Yukio Maruyama et al. PLoS One. .

Abstract

Background: Fatigue is one of the most frequent complications in dialyzed patients and is associated with poorer patient outcomes. Multiple factors are reported to be associated with fatigue development. Of them, the impacts of dialysis modalities remain unknown.

Methods: A total of 194 dialysis patients (mean age, 61±11 years; 134 males; modalities included hemodialysis (HD) in 26, online hemodiafiltration (HDF) in 74, peritoneal dialysis (PD) in 68, and combined therapy with PD and HD in 26 cases) were recruited for this cross-sectional study. Fatigue was assessed using the Profile of Mood States (POMS), a Visual Analogue Scale (VAS), and our original scale of fatigue, and depression was assessed by the Beck Depression Inventory-second edition (BDI-II). Our original scale of fatigue was administered both on dialysis and dialysis-free days to patients on HD and online HDF.

Results: The scores of the POMS, VAS, and our original scale were weakly but significantly inter-related (rho = 0.58, P<0.01; rho = 0.47, P<0.01, and rho = 0.42, P<0.01 between POMS and VAS, POMS and our original scale for fatigue, and VAS and our original scale for fatigue, respectively). The scores of these 3 tests showed no significant differences among the 4 modalities. On multivariate analysis, age, body mass index, creatinine, and employment status were associated with the presence or severity of fatigue, whereas dialysis modality was not. A similar result was obtained in 122 patients without depression. The prevalence of fatigue by our original scale was significantly lower on dialysis-free days than on dialysis days in patients on HD and online HDF.

Conclusions: The results suggest that there is no significant association between different dialysis modalities including HD, online HDF, PD and combined therapy with PD and HD and the prevalence or severity of fatigue.

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Conflict of interest statement

I have read the journal’s policy and the authors of this manuscript have the following competing interests: Y.M. and M.N. have received scholarship funds from Baxter International, Inc. and Terumo Corporation. No other authors have any conflicts of interest to declare. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

Figures

Fig 1
Fig 1. Comparisons of the scores of the POMS, VAS, and our original scale of fatigue in patients receiving HD, online HDF, PD, and combined therapy with PD and HD.
Abbreviations: POMS, Profile of Mood States; VAS, Visual Analogue Scale; HD, hemodialysis; HDF, hemodiafiltration; PD, peritoneal dialysis. * indicates significance.
See this image and copyright information in PMC

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