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. 2021 Apr;123(5):1284-1291.
doi: 10.1002/jso.26423. Epub 2021 Feb 10.

Surgical treatment of primary mobile spine chordoma

Joshua M Kolz  1 , Elizabeth P Wellings  1 , Matthew T Houdek  1 , Michelle J Clarke  2 , Michael J Yaszemski  1 , Peter S Rose  1
Affiliations

Surgical treatment of primary mobile spine chordoma

Joshua M Kolz et al. J Surg Oncol. 2021 Apr.

Abstract

Background and objectives: Chordomas of the mobile spine (C1-L5) are rare malignant tumors. The purpose of this study was to review the outcome of surgical treatment for patients with primary mobile spine chordomas.

Methods: The oncologic outcomes and survival of 26 patients undergoing surgical resection for a primary mobile spine chordoma were assessed over a 25-year period. The mean follow-up was 12 ± 6 years.

Results: The 2-, 5-, and 10-year disease-free survivals were 95%, 61%, and 55%. The local recurrence-free survival was improved in patients receiving en bloc resection with negative margins (83% vs. 35%, p = 0.02) and similar in patients receiving adjuvant radiation therapy (43% vs. 45%, p = 0.30) at 10 years. Debulking of the tumor (hazard ratio [HR] = 6.41, p = 0.01) and a local recurrence (HR = 9.52, p = 0.005) were associated with death due to disease. Complications occurred in 19 (73%) patients, leading to reoperation in 9 (35%) patients; this rate was similar in intralesional and en bloc procedures.

Conclusion: Surgical resection of mobile spine chordomas is associated with a high rate of complications; however, en bloc resection can provide a hope for cure and appears to confer better oncologic outcomes for these tumors without an increase in complications compared to lesser resections.

Keywords: cervical; chordoma; lumbar; mobile spine; outcome; thoracic.

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References

REFERENCES

    1. Shen J, Li CD, Yang HL, et al. Classic chordoma coexisting with benign notochordal cell rest demonstrating different immunohistological expression patterns of brachyury and galectin-3. J Clin Neurosci. 2011;181:96-99.
    1. Walcott BP, Nahed BV, Mohyeldin A, Coumans JV, Kahle KT, Ferreira MJ. Chordoma: current concepts, management, and future directions. Lancet Oncol. 2012;132:e69-e76.
    1. Healey JH, Lane JM. Chordoma: a critical review of diagnosis and treatment. Orthop Clin North Am. 1989;203:417-426.
    1. Choi D, Melcher R, Harms J, Crockard A. Outcome of 132 operations in 97 patients with chordomas of the craniocervical junction and upper cervical spine. Neurosurgery. 2010;661:59-65. Discussion 65.
    1. Yu E, Koffer PP, DiPetrillo TA, Kinsella TJ. Incidence, treatment, and survival patterns for sacral chordoma in the United States, 1974-2011. Front Oncol. 2016;6:203.

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