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Comment
. 2021 Feb 9;54(2):201-204.
doi: 10.1016/j.immuni.2021.01.009.

Microbial memories

Andrea C Wong  1 , Maayan Levy  2
Affiliations
Free article
Comment

Microbial memories

Andrea C Wong et al. Immunity. .
Free article

Abstract

The microbiota impedes pathogen invasion of the intestinal ecosystem, a phenomenon termed colonization resistance. In an upcoming issue of Cell, Stacy et al. describe host-initiated metabolite pathways that functionally alter the microbiota after primary infection, thereby augmenting colonization resistance to subsequent infection.

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  • Infection trains the host for microbiota-enhanced resistance to pathogens.
    Stacy A, Andrade-Oliveira V, McCulloch JA, Hild B, Oh JH, Perez-Chaparro PJ, Sim CK, Lim AI, Link VM, Enamorado M, Trinchieri G, Segre JA, Rehermann B, Belkaid Y. Stacy A, et al. Cell. 2021 Feb 4;184(3):615-627.e17. doi: 10.1016/j.cell.2020.12.011. Epub 2021 Jan 15. Cell. 2021. PMID: 33453153 Free PMC article.

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