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Review
. 2021 Feb 8;13(2):258.
doi: 10.3390/v13020258.

The Key Role of Nucleic Acid Vaccines for One Health

Anders Fomsgaard  1 , Margaret A Liu  2
Affiliations
Review

The Key Role of Nucleic Acid Vaccines for One Health

Anders Fomsgaard et al. Viruses. .

Abstract

The ongoing SARS-CoV-2 pandemic has highlighted both the importance of One Health, i.e., the interactions and transmission of pathogens between animals and humans, and the potential power of gene-based vaccines, specifically nucleic acid vaccines. This review will highlight key aspects of the development of plasmid DNA Nucleic Acid (NA) vaccines, which have been licensed for several veterinary uses, and tested for a number of human diseases, and will explain how an understanding of their immunological and real-world attributes are important for their efficacy, and how they helped pave the way for mRNA vaccines. The review highlights how combining efforts for vaccine development for both animals and humans is crucial for advancing new technologies and for combatting emerging diseases.

Keywords: Cytolytic T Lymphocyte (CTL); DNA vaccines; immune responses; mRNA vaccines; one health; plasmid.

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Conflict of interest statement

MAL owns Merck shares as part of her retirement; Merck is on record as developing mRNA for cancer therapy. AF declares no conflict of interest. The authors alone are responsible for the views expressed in this article and they do not necessarily represent the views, decisions or policies of the institutions with which they are affiliated.

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