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Meta-Analysis
. 2021 Feb 10;21(1):149.
doi: 10.1186/s12885-021-07860-2.

Prognostic values of tumoral MMP2 and MMP9 overexpression in breast cancer: a systematic review and meta-analysis

Hanfang Jiang  1 , Huiping Li  2
Affiliations
Meta-Analysis

Prognostic values of tumoral MMP2 and MMP9 overexpression in breast cancer: a systematic review and meta-analysis

Hanfang Jiang et al. BMC Cancer. .

Abstract

Background: Breast cancer (BC) is a leading cause of cancer-related death in females worldwide. Previous studies have demonstrated that matrix metalloproteinases (MMPs) play key roles in metastasis and are associated with survival in various cancers. The prognostic values of MMP2 and MMP9 expression in BC have been investigated, but the results remain controversial. Thus, we performed the present meta-analysis to investigate the associations between MMP2/9 expressions in tumor cells with clinicopathologic features and survival outcome in BC patients.

Methods: Eligible studies were searched in PubMed, Web of Science, EMBASE, CNKI and Wanfang databases. The associations of MMP2/9 overexpression in tumor cells with overall survival (OS), disease-free survival (DFS) and recurrence-free survival (RFS) were assessed by hazard ratio (HR) and 95% confidence interval (CI). The associations of MMP2/9 overexpression with clinicopathological features were investigated by calculating odds ratio (OR) and 95% CI. Subgroup analysis, sensitivity analysis, meta-regression, and analysis for publication bias were performed.

Results: A total of 41 studies comprising 6517 patients with primary BC were finally included. MMP2 overexpression was associated with an unfavorable OS (HR = 1.60, 95% CI 1.33 -1.94, P < 0.001) while MMP9 overexpression predicted a shorter OS (HR = 1.52, 95% CI 1.30 -1.77, P < 0.001). MMP2 overexpression conferred a higher risk to distant metastasis (OR = 2.69, 95% CI 1.35-5.39, P = 0.005) and MMP9 overexpression correlated with lymph node metastasis (OR = 2.90, 95% CI 1.86 - 4.53, P < 0.001). Moreover, MMP2 and MMP9 overexpression were both associated with higher clinical stage and histological grade in BC patients. MMP9 overexpression was more frequent in patients with larger tumor sizes.

Conclusions: Tumoral MMP2 and MMP9 are promising markers for predicting the prognosis in patients with BC.

Keywords: Breast cancer; MMP2; MMP9; Meta-analysis; Survival.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Flowchart of literature search and selection of eligible studies
Fig. 2
Fig. 2
Forest plot of MMP2 overexpression with overall survival in patients with breast cancer
Fig. 3
Fig. 3
Forest plot of MMP9 overexpression with overall survival in patients with breast cancer
Fig. 4
Fig. 4
Forest plot of MMP2 overexpression with histological grade in patients with breast cancer
Fig. 5
Fig. 5
Forest plot of MMP9 overexpression with tumor size in patients with breast cancer
See this image and copyright information in PMC

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