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Case Reports
. 2021 Feb 3:17:291-296.
doi: 10.2147/NDT.S298005. eCollection 2021.

Cariprazine in Three Acute Patients with Schizophrenia: A Real-World Experience

Jose M Montes  1 , Paloma Montes  2 , Daniel Hernández-Huerta  3
Affiliations
Case Reports

Cariprazine in Three Acute Patients with Schizophrenia: A Real-World Experience

Jose M Montes et al. Neuropsychiatr Dis Treat. .

Abstract

There are still some unmet needs in the treatment of schizophrenia like the persistence of negative symptoms. Cariprazine is a new-generation antipsychotic with partial agonism of the dopamine receptors, distinct from other antipsychotics by its 10 times greater affinity for D3 receptors. This mechanism of action could be especially favorable on patients with predominant negative symptoms. This report is showing three clinical cases of acute schizophrenia exacerbation that required hospitalization and were successfully treated with cariprazine. All of them had predominant positive symptoms and two of them had substance use. Efficacy of cariprazine was also crucial on negative and cognitive symptoms with excellent tolerability.

Keywords: antipsychotics; cariprazine; case report; negative symptoms; schizophrenia.

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Conflict of interest statement

Dr Montes has received grants from and served as consultant, advisor, or CME speaker for Almirall, Angelini, AstraZeneca, Bristol-Myers Squibb, Eli Lilly, Ferrer, GlaxoSmithKline, ISCIII, Janssen-Cilag, Lundbeck, Neuraxpharm, Otsuka, Pfizer, Qualigen, Recordati, Sanofi-Aventis, Servier, and the Spanish Ministry of Science and Innovation (CIBERSAM). Dr Daniel Hernández-Huerta reports personal fees and non-financial support from Janssen, Casen Recordati, Otsuka, Lundbeck, and Angelini, outside the submitted work. The authors report no other conflicts of interest in this work.

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