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. 2021 Jan;13(1):82-91.
doi: 10.21037/jtd-20-2327.

Long-term efficacy and safety of the Dumon stent for benign tracheal stenosis: a meta-analysis

Di-Fei Chen  1 , Yu Chen  1 , Chang-Hao Zhong  1 , Xiao-Bo Chen  1 , Shi-Yue Li  1
Affiliations

Long-term efficacy and safety of the Dumon stent for benign tracheal stenosis: a meta-analysis

Di-Fei Chen et al. J Thorac Dis. 2021 Jan.

Abstract

Background: The short-term efficacy of Dumon stent has been well demonstrated. Across years, however, due to insufficient sample size and absent of the randomized controlled trial, no reliable conclusion could be reach for Dumon stent's long-term efficacy. So, we conducted the first meta-analysis to evaluate the long-term efficacy and safety of the Dumon stent for benign tracheal stenosis.

Methods: Data on related trials were obtained by doing a literature search in PubMed, Web of Science and Cochrane Library. Random-effect and fixed-effect models were used to calculate the efficacy and incidence of complication of Dumon stent placement.

Results: A total of 395 patients from 8 studies were included in this study, revealing that the stability rate was 41.12% (95% CI, 34.85-48.52%) of Dumon stenting. Further, a curative rate of 40.74% (95% CI, 34.92-47.53%), and efficacy of 75.49% (95% CI, 70.89-80.39%) were obtained from this study. Analysis of the incidence of complications indicated 25.04% of migration (95% CI, 17.52-35.79%), 15.66% granulation (95% CI, 9.39-26.11%) and 23.82% of mucus retention 23.82% (95% CI, 13.77-41.20%).

Conclusions: Dumon stent has a moderate efficacy for treating benign tracheal stenosis with approximately 20% incidence of complication, regular bronchoscopy follow-up should be conducted. Thus, further research is required to modified Dumon stenting.

Keywords: Silicone stent; bronchoscopy; meta-analysis; tracheal stenosis.

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/jtd-20-2327). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Flowchart demonstrating inclusion and exclusion criteria.
Figure 2
Figure 2
Forest plot for the meta-analysis of efficacy indexes. CI, confidence interval.
Figure 3
Figure 3
Forest plot for the meta-analysis of safety events. CI, confidence interval.
Figure 4
Figure 4
Forest plots for subgroup meta-analysis of curative rate based on median follow-up. CI, confidence interval.
Figure 5
Figure 5
Funnel plot of studies included in this meta-analysis.
See this image and copyright information in PMC

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