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Comment
. 2021 Apr 5;153(4):e202012805.
doi: 10.1085/jgp.202012805.

Not so transport incompetent after all: Revisiting a CLC-7 mutant sheds new mechanistic light on lysosomal physiology

Alessio Accardi  1   2   3
Affiliations
Comment

Not so transport incompetent after all: Revisiting a CLC-7 mutant sheds new mechanistic light on lysosomal physiology

Alessio Accardi. J Gen Physiol. .

Abstract

Accardi reviews data on the lysosomal 2 Cl−/1 H+ antiporter ClC-7.

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References

    1. Accardi, A. 2015. Structure and gating of CLC channels and exchangers. J. Physiol. 593:4129–4138. 10.1113/JP270575 - DOI - PMC - PubMed
    1. Accardi, A., Walden M., Nguitragool W., Jayaram H., Williams C., and Miller C.. 2005. Separate ion pathways in a Cl-/H+ exchanger. J. Gen. Physiol. 126:563–570. 10.1085/jgp.200509417 - DOI - PMC - PubMed
    1. Alekov, A.K., and Fahlke C.. 2009. Channel-like slippage modes in the human anion/proton exchanger ClC-4. J. Gen. Physiol. 133:485–496. 10.1085/jgp.200810155 - DOI - PMC - PubMed
    1. Appelqvist, H., Wäster P., Kågedal K., and Öllinger K.. 2013. The lysosome: from waste bag to potential therapeutic target. J. Mol. Cell Biol. 5:214–226. 10.1093/jmcb/mjt022 - DOI - PubMed
    1. Chavan, T.S., Cheng R.C., Jian T., Mathews I.I., Stein R.A., Kohel A., Mchaourab H.S., Tajkhorshid E., and Maduke M.. 2020. A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl−/H+ transport cycle. eLife. 9:e53479. 10.7554/eLife.53479 - DOI - PMC - PubMed

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