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Comment
. 2021 Mar 3;29(3):896-897.
doi: 10.1016/j.ymthe.2021.02.003. Epub 2021 Feb 10.

A Tolerizing mRNA Vaccine against Autoimmunity?

Roberto Furlan  1
Affiliations
Comment

A Tolerizing mRNA Vaccine against Autoimmunity?

Roberto Furlan. Mol Ther. .
No abstract available

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Figures

Figure 1
Figure 1
Principles of Activating or Tolerizing Immunization. Liposomes constituted using pro-inflammatory lipids and carrying a viral antigen mRNA are injected in muscles to induce local antigen presenting cells (APCs) to uptake and translate the mRNA to its corresponding protein in a pro-inflammatory environment, consequently inducing downstream activation of antigen-specific T cells (upper panel). In contrast, non-inflammatory liposomes injected in the blood to deliver a mRNA that lacks danger signals results in induction of antigen-specific T cell tolerizance and inhibition of autoimmunity (lower panel).
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