Letter to the editor - Comparative efficacy of racemic ketamine and esketamine for depression: A systematic review and meta-analysis

Affiliations

¹ Postgraduate Program in Medicine and Health, Faculty of Medicine, Federal University of Bahia, Salvador, Brazil; Neuropsychopharmacology Laboratory, Federal University of Bahia, Salvador, Brazil.
² Postgraduate Program in Medicine and Health, Faculty of Medicine, Federal University of Bahia, Salvador, Brazil; Neuropsychopharmacology Laboratory, Federal University of Bahia, Salvador, Brazil; Division of Psychiatry, Professor Edgard Santos University Hospital, Federal University of Bahia, Brazil.
³ Postgraduate Program in Medicine and Health, Faculty of Medicine, Federal University of Bahia, Salvador, Brazil; Neuropsychopharmacology Laboratory, Federal University of Bahia, Salvador, Brazil; Neuroscience and Mental Health Department, Faculty of Medicine, Federal University of Bahia, Salvador, Brazil.
⁴ Postgraduate Program in Medicine and Health, Faculty of Medicine, Federal University of Bahia, Salvador, Brazil; Neuropsychopharmacology Laboratory, Federal University of Bahia, Salvador, Brazil; Division of Psychiatry, Professor Edgard Santos University Hospital, Federal University of Bahia, Brazil; Neuroscience and Mental Health Department, Faculty of Medicine, Federal University of Bahia, Salvador, Brazil. Electronic address: lcq@ufba.br.

Comment

Breno Souza-Marques et al. J Affect Disord. 2021.

. 2021 Mar 15:283:265-266.

doi: 10.1016/j.jad.2021.01.026. Epub 2021 Jan 20.

¹ Postgraduate Program in Medicine and Health, Faculty of Medicine, Federal University of Bahia, Salvador, Brazil; Neuropsychopharmacology Laboratory, Federal University of Bahia, Salvador, Brazil.
² Postgraduate Program in Medicine and Health, Faculty of Medicine, Federal University of Bahia, Salvador, Brazil; Neuropsychopharmacology Laboratory, Federal University of Bahia, Salvador, Brazil; Division of Psychiatry, Professor Edgard Santos University Hospital, Federal University of Bahia, Brazil.
³ Postgraduate Program in Medicine and Health, Faculty of Medicine, Federal University of Bahia, Salvador, Brazil; Neuropsychopharmacology Laboratory, Federal University of Bahia, Salvador, Brazil; Neuroscience and Mental Health Department, Faculty of Medicine, Federal University of Bahia, Salvador, Brazil.
⁴ Postgraduate Program in Medicine and Health, Faculty of Medicine, Federal University of Bahia, Salvador, Brazil; Neuropsychopharmacology Laboratory, Federal University of Bahia, Salvador, Brazil; Division of Psychiatry, Professor Edgard Santos University Hospital, Federal University of Bahia, Brazil; Neuroscience and Mental Health Department, Faculty of Medicine, Federal University of Bahia, Salvador, Brazil. Electronic address: lcq@ufba.br.

No abstract available

Keywords: Esketamine; Ketamine; Treatment-resistant depression.

Comment on

Intravenous Esketamine in Adult Treatment-Resistant Depression: A Double-Blind, Double-Randomization, Placebo-Controlled Study.
Singh JB, Fedgchin M, Daly E, Xi L, Melman C, De Bruecker G, Tadic A, Sienaert P, Wiegand F, Manji H, Drevets WC, Van Nueten L. Singh JB, et al. Biol Psychiatry. 2016 Sep 15;80(6):424-431. doi: 10.1016/j.biopsych.2015.10.018. Epub 2015 Nov 3. Biol Psychiatry. 2016. PMID: 26707087 Clinical Trial.
Efficacy and safety of adjunctive therapy using esketamine or racemic ketamine for adult treatment-resistant depression: A randomized, double-blind, non-inferiority study.
Correia-Melo FS, Leal GC, Vieira F, Jesus-Nunes AP, Mello RP, Magnavita G, Caliman-Fontes AT, Echegaray MVF, Bandeira ID, Silva SS, Cavalcanti DE, Araújo-de-Freitas L, Sarin LM, Tuena MA, Nakahira C, Sampaio AS, Del-Porto JA, Turecki G, Loo C, Lacerda ALT, Quarantini LC. Correia-Melo FS, et al. J Affect Disord. 2020 Mar 1;264:527-534. doi: 10.1016/j.jad.2019.11.086. Epub 2019 Nov 14. J Affect Disord. 2020. PMID: 31786030 Clinical Trial.
Comparative efficacy of racemic ketamine and esketamine for depression: A systematic review and meta-analysis.
Bahji A, Vazquez GH, Zarate CA Jr. Bahji A, et al. J Affect Disord. 2021 Jan 1;278:542-555. doi: 10.1016/j.jad.2020.09.071. Epub 2020 Sep 23. J Affect Disord. 2021. PMID: 33022440 Free PMC article.