The Development of a WTC Environmental Health Center Pan-Cancer Database

doi:10.3390/ijerph18041646

. 2021 Feb 9;18(4):1646.

doi: 10.3390/ijerph18041646.

The Development of a WTC Environmental Health Center Pan-Cancer Database

Yongzhao Shao^{1

2

3

4}, Nedim Durmus^{3

5}, Yian Zhang^{1

3}, Sultan Pehlivan^{3

5}, Maria-Elena Fernandez-Beros^{3

5}, Lisette Umana^{3

5}, Rachel Corona^{3

5}, Adrienne Addessi³, Sharon A Abbott³, Sheila Smyth-Giambanco³, Alan A Arslan^{1

2

3

4

6}, Joan Reibman^{2

3

5}

Affiliations

¹ Division of Biostatistics, Department of Population Health, NYU Grossman School of Medicine (NYUGSOM), New York University, New York, NY 10016, USA.
² Department of Environmental Medicine, NYUG-SOM, New York University, New York, NY 10016, USA.
³ World Trade Center Environmental Health Center, NYC Health + Hospitals, New York, NY 10016, USA.
⁴ NYU Perlmutter Comprehensive Cancer Center, New York, NY 10016, USA.
⁵ Division of Pulmonary Medicine, School of Medicine (SOM), NYUG-SOM, New York University, New York, NY 10016, USA.
⁶ Department of Obstetrics and Gynecology, School of Medicine (SOM), NYUG-SOM, New York University, New York, NY 10016, USA.

PMID: 33572220
PMCID: PMC7916067
DOI: 10.3390/ijerph18041646

The Development of a WTC Environmental Health Center Pan-Cancer Database

Yongzhao Shao et al. Int J Environ Res Public Health. 2021.

. 2021 Feb 9;18(4):1646.

doi: 10.3390/ijerph18041646.

Authors

Affiliations

¹ Division of Biostatistics, Department of Population Health, NYU Grossman School of Medicine (NYUGSOM), New York University, New York, NY 10016, USA.
² Department of Environmental Medicine, NYUG-SOM, New York University, New York, NY 10016, USA.
³ World Trade Center Environmental Health Center, NYC Health + Hospitals, New York, NY 10016, USA.
⁴ NYU Perlmutter Comprehensive Cancer Center, New York, NY 10016, USA.
⁵ Division of Pulmonary Medicine, School of Medicine (SOM), NYUG-SOM, New York University, New York, NY 10016, USA.
⁶ Department of Obstetrics and Gynecology, School of Medicine (SOM), NYUG-SOM, New York University, New York, NY 10016, USA.

PMID: 33572220
PMCID: PMC7916067
DOI: 10.3390/ijerph18041646

Abstract

(1) Background: Recent studies have reported elevated risks of multiple cancers in the World Trade Center (WTC) affected community members (also called WTC "Survivors"). The large variety of WTC-cancers created a need to develop a comprehensive cancer database. This paper describes the development of a pan-cancer database at the WTC Environmental Health Center (EHC) Data Center. (2) Methods: A new REDCap-based pan-cancer database was created using the pathology reports and available biomarker data of confirmed cancer cases after review by a cancer epidemiologist, a pathologist, physicians and biostatisticians. (3) Results: The WTC EHC pan-cancer database contains cancer characteristics and emerging biomarker information for cancers of individuals enrolled in the WTC EHC and diagnosed after 11 September 2001 and up to 31 December 2019 obtained from WTC EHC clinical records, pathological reports and state cancer registries. As of 31 December 2019, the database included 3440 cancer cases with cancer characteristics and biomarker information. (4) Conclusions: This evolving database represents an important resource for the scientific community facilitating future research about the etiology, heterogeneity, characteristics and outcomes of cancers and comorbid mental health conditions, cancer economics and gene-environment interaction in the unique population of WTC survivors.

Keywords: September 11th; WTC Environmental Health Center; WTC survivors; biomarkers; cancer incidence; clinical cancer database.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
WTC EHC pan-cancer database overview.

**Figure 2**
Cumulative hazards for first primary cancer diagnosis from 11 September 2001 among cancer patients in WTC EHC pan-cancer database.

**Figure 3**
Top 15 cancer diagnoses in WTC EHC pan-cancer database.

See this image and copyright information in PMC

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Tuminello S, Ashebir YA, Schroff C, Ramaswami S, Durmus N, Chen Y, Snuderl M, Shao Y, Reibman J, Arslan AA. Tuminello S, et al. Environ Epidemiol. 2024 Jun 4;8(3):e313. doi: 10.1097/EE9.0000000000000313. eCollection 2024 Jun. Environ Epidemiol. 2024. PMID: 38841706 Free PMC article.
Breast Cancer Characteristics in the Population of Survivors Participating in the World Trade Center Environmental Health Center Program 2002-2019.
Arslan AA, Zhang Y, Durmus N, Pehlivan S, Addessi A, Schnabel F, Shao Y, Reibman J. Arslan AA, et al. Int J Environ Res Public Health. 2021 Jul 15;18(14):7555. doi: 10.3390/ijerph18147555. Int J Environ Res Public Health. 2021. PMID: 34300003 Free PMC article.
Lung Cancer Characteristics in the World Trade Center Environmental Health Center.
Durmus N, Pehlivan S, Zhang Y, Shao Y, Arslan AA, Corona R, Henderson I, Sterman DH, Reibman J. Durmus N, et al. Int J Environ Res Public Health. 2021 Mar 7;18(5):2689. doi: 10.3390/ijerph18052689. Int J Environ Res Public Health. 2021. PMID: 33800009 Free PMC article.
World Trade Center Exposure, DNA Methylation Changes, and Cancer: A Review of Current Evidence.
Tuminello S, Nguyen E, Durmus N, Alptekin R, Yilmaz M, Crisanti MC, Snuderl M, Chen Y, Shao Y, Reibman J, Taioli E, Arslan AA. Tuminello S, et al. Epigenomes. 2023 Dec 8;7(4):31. doi: 10.3390/epigenomes7040031. Epigenomes. 2023. PMID: 38131903 Free PMC article. Review.
Characteristics of survivors enrolled in the World Trade Center Health Program.
Liu R, Santiago-Colón A, Butturini E, Kubale TL, Reibman J. Liu R, et al. Arch Environ Occup Health. 2024;79(5-6):185-198. doi: 10.1080/19338244.2024.2410495. Epub 2024 Oct 31. Arch Environ Occup Health. 2024. PMID: 39482829 Free PMC article.

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References

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1. Lippmann M., Cohen M.D., Chen L.C. Health effects of World Trade Center (WTC) Dust: An unprecedented disaster with inadequate risk management. Crit. Rev. Toxicol. 2015;45:492–530. doi: 10.3109/10408444.2015.1044601. - DOI - PMC - PubMed
1. Reibman J., Levy-Carrick N., Miles T., Flynn K., Hughes C., Crane M., Lucchini R.G. Destruction of the World Trade Center Towers. Lessons Learned from an Environmental Health Disaster. Ann. Am. Thorac. Soc. 2016;13:577–583. doi: 10.1513/AnnalsATS.201509-572PS. - DOI - PMC - PubMed
1. Trasande L., Fiorino E.K., Attina T., Berger K., Goldring R., Chemtob C., Reibman J. Associations of World Trade Center exposures with pulmonary and cardiometabolic outcomes among children seeking care for health concerns. Sci. Total Environ. 2013;444:320–326. doi: 10.1016/j.scitotenv.2012.11.097. - DOI - PMC - PubMed

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[1] Lioy P.J., Gochfeld M. Lessons learned on environmental, occupational, and residential exposures from the attack on the World Trade Center. Am. J. Ind. Med. 2002;42:560–565. doi: 10.1002/ajim.10160. - DOI - PubMed

[2] Lioy P.J., Gochfeld M. Lessons learned on environmental, occupational, and residential exposures from the attack on the World Trade Center. Am. J. Ind. Med. 2002;42:560–565. doi: 10.1002/ajim.10160. - DOI - PubMed

[3] Landrigan P.J., Lioy P.J., Thurston G., Berkowitz G., Chen L.C., Chillrud S.N., Gavett S.H., Georgopoulos P.G., Geyh A.S., Levin S., et al. Health and environmental consequences of the world trade center disaster. Environ. Health Perspect. 2004;112:731–739. doi: 10.1289/ehp.6702. - DOI - PMC - PubMed

[4] Landrigan P.J., Lioy P.J., Thurston G., Berkowitz G., Chen L.C., Chillrud S.N., Gavett S.H., Georgopoulos P.G., Geyh A.S., Levin S., et al. Health and environmental consequences of the world trade center disaster. Environ. Health Perspect. 2004;112:731–739. doi: 10.1289/ehp.6702. - DOI - PMC - PubMed

[5] Lippmann M., Cohen M.D., Chen L.C. Health effects of World Trade Center (WTC) Dust: An unprecedented disaster with inadequate risk management. Crit. Rev. Toxicol. 2015;45:492–530. doi: 10.3109/10408444.2015.1044601. - DOI - PMC - PubMed

[6] Lippmann M., Cohen M.D., Chen L.C. Health effects of World Trade Center (WTC) Dust: An unprecedented disaster with inadequate risk management. Crit. Rev. Toxicol. 2015;45:492–530. doi: 10.3109/10408444.2015.1044601. - DOI - PMC - PubMed

[7] Reibman J., Levy-Carrick N., Miles T., Flynn K., Hughes C., Crane M., Lucchini R.G. Destruction of the World Trade Center Towers. Lessons Learned from an Environmental Health Disaster. Ann. Am. Thorac. Soc. 2016;13:577–583. doi: 10.1513/AnnalsATS.201509-572PS. - DOI - PMC - PubMed

[8] Reibman J., Levy-Carrick N., Miles T., Flynn K., Hughes C., Crane M., Lucchini R.G. Destruction of the World Trade Center Towers. Lessons Learned from an Environmental Health Disaster. Ann. Am. Thorac. Soc. 2016;13:577–583. doi: 10.1513/AnnalsATS.201509-572PS. - DOI - PMC - PubMed

[9] Trasande L., Fiorino E.K., Attina T., Berger K., Goldring R., Chemtob C., Reibman J. Associations of World Trade Center exposures with pulmonary and cardiometabolic outcomes among children seeking care for health concerns. Sci. Total Environ. 2013;444:320–326. doi: 10.1016/j.scitotenv.2012.11.097. - DOI - PMC - PubMed

[10] Trasande L., Fiorino E.K., Attina T., Berger K., Goldring R., Chemtob C., Reibman J. Associations of World Trade Center exposures with pulmonary and cardiometabolic outcomes among children seeking care for health concerns. Sci. Total Environ. 2013;444:320–326. doi: 10.1016/j.scitotenv.2012.11.097. - DOI - PMC - PubMed

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The Development of a WTC Environmental Health Center Pan-Cancer Database

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The Development of a WTC Environmental Health Center Pan-Cancer Database

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