Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Jan 29;13(3):519.
doi: 10.3390/cancers13030519.

Brain Metastases from Uterine Cervical and Endometrial Cancer

Mayumi Kobayashi Kato  1 , Yasuhito Tanase  1 , Masaya Uno  1 , Mitsuya Ishikawa  1 , Tomoyasu Kato  1
Affiliations
Review

Brain Metastases from Uterine Cervical and Endometrial Cancer

Mayumi Kobayashi Kato et al. Cancers (Basel). .

Abstract

Reports on brain metastases (BMs) from uterine cervical carcinoma (CC) and uterine endometrial carcinoma (EC) have recently increased due to the development of massive databases and improvements in diagnostic procedures. This review separately investigates the prevalence, clinical characteristics, clinical presentation, diagnosis, treatment, and prognosis of BMs from CC and uterine endometrial carcinoma EC. For patients with CC, early-stage disease and poorly differentiated carcinoma lead to BMs, and elderly age, poor performance status, and multiple BMs are listed as poor prognostic factors. Advanced-stage disease and high-grade carcinoma are high-risk factors for BMs from EC, and multiple metastases and extracranial metastases, or unimodal therapies, are possibly factors indicating poor prognosis. There is no "most effective" therapy that has gained consensus for the treatment of BMs. Treatment decisions are based on clinical status, number of the metastases, tumor size, and metastases at distant organs. Surgical resection followed by adjuvant radiotherapy appears to be the best treatment approach to date. Stereotactic ablative radiation therapy has been increasingly associated with good outcomes in preserving cognitive functions. Despite treatment, patients died within 1 year after the BM diagnosis. BMs from uterine cancer remain quite rare, and the current evidence is limited; thus, further studies are needed.

Keywords: brain metastases; cervical cancer; endometrioid cancer; prognosis; treatment.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Figures

Figure 1
Figure 1
Treatment strategies for Brain metastases from cervical cancer and endometrial cancer. HA-WBRT: hippocampal avoidance using intensity-modulated radiotherapy during whole-brain radiotherapy, KPS: Karnofsky performance status, SRS: stereotactic radiosurgery, WBRT: whole-brain radiotherapy.
See this image and copyright information in PMC

References

    1. Howlader N., Krapcho M., Miller D., Brest A., Yu M., Ruhl J., Tatalovich Z., Mariotto A., Lewis D.R., Chen H.S., et al. SEER Cancer Statistics Review, 1975–2017. National Cancer Institute; Bethesda, MD, USA: 2020.
    1. Bray F., Ferlay J., Soerjomataram I., Siegel R.L., Torre L.A., Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 2018;68:394–424. doi: 10.3322/caac.21492. - DOI - PubMed
    1. Surveillance E., End Results Program . Cancer Stat Facts: Cervical Cancer. National Cancer Institute; [(accessed on 20 December 2020)]. Available online: https://seer.cancer.gov/statfacts/html/cervix.html.
    1. Surveillance E., End Results Program . Cancer Stat Fscts: Uterine Cancer. National Cancer Institute; [(accessed on 20 December 2020)]. Available online: https://seer.cancer.gov/statfacts/html/corp.html.
    1. Li H., Wu X., Cheng X. Advances in diagnosis and treatment of metastatic cervical cancer. J. Gynecol. Oncol. 2016;27:e43. doi: 10.3802/jgo.2016.27.e43. - DOI - PMC - PubMed

LinkOut - more resources