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Review
. 2021 Jan 30;10(2):138.
doi: 10.3390/pathogens10020138.

Potential SARS-CoV-2 Immune Correlates of Protection in Infection and Vaccine Immunization

Yongjun Sui  1 , Yonas Bekele  1 , Jay A Berzofsky  1
Affiliations
Review

Potential SARS-CoV-2 Immune Correlates of Protection in Infection and Vaccine Immunization

Yongjun Sui et al. Pathogens. .

Abstract

Both SARS-CoV-2 infections and vaccines induce robust immune responses. Current data suggested that high neutralizing antibody titers with sustained Th1 responses might correlate with protection against viral transmission and disease development and severity. In addition, genetic and innate immune factors, including higher levels of type I interferons, as well as the induction of trained immunity and local mucosal immunity also contribute to lower risk of infection and amelioration of disease severity. The identification of immune correlates of protection will facilitate the development of effective vaccines and therapeutics strategies.

Keywords: SARS-CoV-2; T-cell immunity; Th1 responses; innate immunity; mucosal immunity; neutralizing antibody; trained immunity; type I interferon.

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Conflict of interest statement

The authors declare no conflict of interest.

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