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. 2021 Feb;2(2):79-85.
doi: 10.1302/2633-1462.22.BJO-2020-0173.R1.

A prospective longitudinal study investigating outcomes including patient-reported outcome measures after surgery for metastatic bone disease

Samantha Downie  1 , Alison Stillie  2 , Matthew Moran  1 , Catherine Sudlow  3 , A Hamish R W Simpson  1
Affiliations

A prospective longitudinal study investigating outcomes including patient-reported outcome measures after surgery for metastatic bone disease

Samantha Downie et al. Bone Jt Open. 2021 Feb.

Abstract

Aims: Surgery is often indicated in patients with metastatic bone disease (MBD) to improve pain and maximize function. Few studies are available which report on clinically meaningful outcomes such as quality of life, function, and pain relief after surgery for MBD. This is the published protocol for the Bone Metastasis Audit - Patient Reported Outcomes (BoMA-PRO) multicentre MBD study. The primary objective is to ascertain patient-reported quality of life at three to 24 months post-surgery for MBD.

Methods: This will be a prospective, longitudinal study across six UK orthopaedic centres powered to identify the influence of ten patient variables on quality of life at three months after surgery for MBD. Adult patients managed for bone metastases will be screened by their treating consultant and posted out participant materials. If they opt in to participate, they will receive questionnaire packs at regular intervals from three to 24 months post-surgery and their electronic records will be screened until death or five years from recruitment. The primary outcome is quality of life as measured by the European Organisation for Research and the Treatment of Cancer Quality of Life questionnaire (EORTC-QLQ) C30 questionnaire. The protocol has been approved by the Newcastle & North Tyneside 2 Research Ethics Committee (REC ref 19/NE/0303) and the study is funded by the Royal College of Physicians and Surgeons of Glasgow (RCPSG) and the Association for Cancer Surgery (BASO-ACS).

Discussion: This will be the first powered study internationally to investigate patient-reported outcomes after orthopaedic treatment for bone metastases. We will assess quality of life, function, and pain relief at three to 24 months post-surgery and identify which patient variables are significantly associated with a good outcome after MBD treatment. Cite this article: Bone Jt Open 2021;2(2):79-85.

Keywords: MBD; Metastatic bone disease; Metastatic fracture; Pathological fracture; Patient reported outcomes.

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Figures

Fig. 1
Fig. 1
Flowchart detailing process of participant identification, consent and follow-up for the Bone Metastasis Audit - Patient Reported Outcomes (BoMA-PRO) multicentre study.
See this image and copyright information in PMC

References

    1. Downie S, Lai FY, Joss J, Adamson D, Jariwala AC. The metastatic early prognostic (MEP) score. Bone Joint J. 2020;102-B(1):72–81. - PubMed
    1. Choy W-S, Kim KJ, Lee SK, et al. . Surgical treatment of pathological fractures occurring at the proximal femur. Yonsei Med J. 2015;56(2):460–465. - PMC - PubMed
    1. Ratasvuori M, Wedin R, Keller J, et al. . Insight opinion to surgically treated metastatic bone disease: Scandinavian sarcoma group skeletal metastasis Registry report of 1195 operated skeletal metastasis. Surg Oncol. 2013;22(2):132–138. - PubMed
    1. British Orthopaedic Oncology Society (BOOS) Metastatic bone disease: a guide to good practice. 2015. http://www.boos.org.uk/wp-content/uploads/2016/03/BOOS-MBD-2016-BOA.pdf
    1. Blank AT, Lerman DM, Shaw S, et al. . PROMIS® scores in operative metastatic bone disease patients: A multicenter, prospective study. J Surg Oncol. 2018;118(3):532–535. - PubMed