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Comment
. 2021 Feb 11;19(1):63.
doi: 10.1186/s12967-021-02723-7.

Biomarkers of COVID-19 severity may not serve patients with polycystic ovary syndrome

Abu Saleh Md Moin  1 , Manjula Nandakumar  1 , Thozhukat Sathyapalan  2 , Stephen L Atkin #  3 , Alexandra E Butler #  4
Affiliations
Comment

Biomarkers of COVID-19 severity may not serve patients with polycystic ovary syndrome

Abu Saleh Md Moin et al. J Transl Med. .
No abstract available

Keywords: Biomarkers; COVID-19; Coagulation factors; Platelet degranulation; Polycystic ovary syndrome; SARS-CoV-2.

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Conflict of interest statement

No authors have any conflict of interest or competing interests to declare.

Figures

Fig. 1
Fig. 1
The protein–protein interaction tool STRING 11.0 (Search Tool for the Retrieval of Interacting Genes) was used to visualize the significantly different proteins in PCOS compared to controls, and for all of the proteomic proteins in COVID-19 disease severity described by others [1] (https://string-db.org/). Interactions between proteins are evidence-based and collated from databases, experiments, neighborhood, gene fusion, co-occurrence, text mining, co-expression, and homology. Here, we determined the relationships between the platelet degranulation (a) and complement and coagulation cascade proteins (b) presented in the study by Shu et al. [1] that were significantly different between non-COVID infected PCOS and control women. a Platelet degranulation proteins that differed significantly between PCOS and control women, indicating their relationship to one another. b Complement and coagulation cascade proteins that differed significantly between PCOS and control women, indicating their relationship to one another. c Combined platelet degranulation and complement and coagulation cascade proteins that differed significantly in PCOS, indicating their relationships to one another
See this image and copyright information in PMC

Comment on

  • Plasma Proteomics Identify Biomarkers and Pathogenesis of COVID-19.
    Shu T, Ning W, Wu D, Xu J, Han Q, Huang M, Zou X, Yang Q, Yuan Y, Bie Y, Pan S, Mu J, Han Y, Yang X, Zhou H, Li R, Ren Y, Chen X, Yao S, Qiu Y, Zhang DY, Xue Y, Shang Y, Zhou X. Shu T, et al. Immunity. 2020 Nov 17;53(5):1108-1122.e5. doi: 10.1016/j.immuni.2020.10.008. Epub 2020 Oct 20. Immunity. 2020. PMID: 33128875 Free PMC article.

References

    1. Shu T, Ning W, Wu D, Xu J, Han Q, Huang M, et al. Plasma proteomics identify biomarkers and pathogenesis of COVID-19. Immunity. 2020;53(5):1108–22.e5. doi: 10.1016/j.immuni.2020.10.008. - DOI - PMC - PubMed
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    1. Moin ASM, Sathyapalan T, Atkin SL, Butler AE. Renin-angiotensin system overactivation in polycystic ovary syndrome, a risk for SARS-CoV-2 infection? Metabolism open. 2020;7:100052. doi: 10.1016/j.metop.2020.100052. - DOI - PMC - PubMed
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