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. 2021 Feb;26(6):2100096.
doi: 10.2807/1560-7917.ES.2021.26.6.2100096.

Impact of age, ethnicity, sex and prior infection status on immunogenicity following a single dose of the BNT162b2 mRNA COVID-19 vaccine: real-world evidence from healthcare workers, Israel, December 2020 to January 2021

Kamal Abu Jabal  1   2   3 , Hila Ben-Amram  1   2 , Karine Beiruti  1 , Yunis Batheesh  1 , Christian Sussan  1 , Salman Zarka  1   3 , Michael Edelstein  1   3
Affiliations

Impact of age, ethnicity, sex and prior infection status on immunogenicity following a single dose of the BNT162b2 mRNA COVID-19 vaccine: real-world evidence from healthcare workers, Israel, December 2020 to January 2021

Kamal Abu Jabal et al. Euro Surveill. 2021 Feb.

Abstract

The BNT162b2 mRNA COVID-19 vaccine showed high efficacy in clinical trials but observational data from populations not included in trials are needed. We describe immunogenicity 21 days post-dose 1 among 514 Israeli healthcare workers by age, ethnicity, sex and prior COVID-19 infection. Immunogenicity was similar by ethnicity and sex but decreased with age. Those with prior infection had antibody titres one magnitude order higher than naïve individuals regardless of the presence of detectable IgG antibodies pre-vaccination.

Keywords: COVID-19; Israel; immunogenicity; vaccine.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure
Figure
Anti SARS-CoV-2 spike IgG antibody levels among healthcare workers, 21 days post first-dose of BNT162b2 mRNA COVID19 vaccine by age (A) and prior infection status (B), Israel, December 2020 to January 2021 (n = 475)
See this image and copyright information in PMC

Comment in

References

    1. World Health Organization (WHO). WHO Coronavirus Disease (COVID-19) Dashboard. Geneva: WHO. [Accessed: 25 Jan 2021]. Available from: https://covid19.who.int/
    1. Baden LR, El Sahly HM, Essink B, Kotloff K, Frey S, Novak R, et al. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. N Engl J Med. 2021;384(5):403-16. 10.1056/NEJMoa2035389 - DOI - PMC - PubMed
    1. Polack FP, Thomas SJ, Kitchin N, Absalon J, Gurtman A, Lockhart S, et al. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. N Engl J Med. 2020;383(27):2603-15. 10.1056/NEJMoa2034577 - DOI - PMC - PubMed
    1. Ramasamy MN, Minassian AM, Ewer KJ, Flaxman AL, Folegatti PM, Owens DR, et al. Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial. Lancet. 2021;396(10267):1979-93. 10.1016/S0140-6736(20)32466-1 - DOI - PMC - PubMed
    1. Aldridge RW, Lewer D, Katikireddi SV, Mathur R, Pathak N, Burns R, et al. Black, Asian and Minority Ethnic groups in England are at increased risk of death from COVID-19: indirect standardisation of NHS mortality data. Wellcome Open Res. 2020;5:88. 10.12688/wellcomeopenres.15922.2 - DOI - PMC - PubMed

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