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. 2021 Feb;230(3):143-147.
doi: 10.1038/s41415-021-2601-3. Epub 2021 Feb 12.

Orofacial manifestations of sickle cell disease: implications for dental clinicians

Sandra Girgis  1 , Leo Cheng  2 , Dimitris Tsitsikas  3 , Christopher Sproat  4
Affiliations

Orofacial manifestations of sickle cell disease: implications for dental clinicians

Sandra Girgis et al. Br Dent J. 2021 Feb.

Abstract

Sickle cell disease is a multisystem disease associated with episodes of acute illness and progressive organ damage. It is one of the most common severe monogenic disorders worldwide and is now the fastest growing genetic disorder in the UK. Dental awareness of orofacial manifestation varies geographically due to the inheritance pattern and patient population affected by the disease. This article details the epidemiology, pathophysiology and the orofacial manifestations in light of current literature.

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