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. 2021 Feb 4:16:215-223.
doi: 10.2147/COPD.S285927. eCollection 2021.

Application Value of Broadband 3-Dimensional Impulse Oscillometry in COPD

Zhonghao Tang #  1 , Minjing Li #  1 , Guokun Chu  1 , Yan Mou  1 , Qi Chen  2 , Huili Zhu  1
Affiliations

Application Value of Broadband 3-Dimensional Impulse Oscillometry in COPD

Zhonghao Tang et al. Int J Chron Obstruct Pulmon Dis. .

Abstract

Objective: To explore the correlation of respiratory resistance in stable COPD patients measured by broadband 3-dimensional impulse oscillometry (3D-IOS) and traditional pulmonary function test (PFT). To access the diagnostic value of 3D-IOS in COPD.

Methods: A total of 107 COPD patients and 61 healthy subjects as controls were chosen to collect and statistically analyze the data of R5, R5-R20, R20, X5 and Fres measured by broadband 3D-IOS and FEV1%pred, FVC%pred and FEV1/FVC by PFTs. The diagnostic value of broadband 3D-IOS parameters in COPD was evaluated by receiver operating characteristic curve (ROC). 3D-colored images used to show dynamic changes of respiratory resistance in COPD.

Results: The COPD group showed significant increases in R5, R20, R5-R20 and Fres, and a decrease in X5 (P<0.05). With the increase of GOLD grade, R5, R5-R20 and Fres increased whereas X5 decreased (P<0.05). Compared with FEV1%pred, FVC%pred and FEV1/FVC in the COPD group, R5, R5-R20 and Fres were negatively collated (P<0.05), whereas X5 was positively collated (P<0.01). R20 was uncorrelated with the traditional lung function parameters (P>0.05). Fres and FEV1/FVC (r=-0.467), and X5 and FEV1%pred (r=0.412) showed the strongest correlation. The AUC of R5, R5-R20, X5 and Fres was 0.7808, 0.7659, 0.8947 and 0.9095, respectively. Typical 3D-colored images of COPD displayed a green pattern in the inhalation phase and yellow-red-blue graduation in the expiration phase.

Conclusion: R5, R5-R20, X5 and Fres measured by broadband 3D-IOS can reflect the change of respiratory resistance in COPD. And they have good correlation with the traditional lung function parameters (FEV1%pred, FVC%pred, FEV1/FVC). Fres has the highest diagnostic accuracy. Comprehensive analysis of R5, R5-R20, Fres and X5 helps to determine the degree of respiratory obstruction in COPD. X5 and Fres can reflect changes in lung tissue compliance. 3D-colored images can visually show the change of respiratory resistance and reactance in COPD.

Keywords: 3-dimensional impulse oscillometry; chronic obstructive pulmonary disease; pulmonary function test; respiratory resistance.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
ROC of R5.
Figure 2
Figure 2
ROC of R5–R20.
Figure 3
Figure 3
ROC of X5.
Figure 4
Figure 4
ROC of Fres.
Figure 5
Figure 5
3D-colored images of COPD patient.
Figure 6
Figure 6
3D-colored images of healthy control.
See this image and copyright information in PMC

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