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Review
. 2021 Jan 26:8:615649.
doi: 10.3389/fmed.2021.615649. eCollection 2021.

Antimicrobial Resistance in Enterobacterales and Its Contribution to Sepsis in Sub-saharan Africa

Kathleen Tompkins  1 , Jonathan J Juliano  1   2   3 , David van Duin  1
Affiliations
Review

Antimicrobial Resistance in Enterobacterales and Its Contribution to Sepsis in Sub-saharan Africa

Kathleen Tompkins et al. Front Med (Lausanne). .

Abstract

Antibiotic resistant Enterobacterales (formerly Enterobactereaceae) are a growing threat to Sub-Saharan Africa. Genes causing antibiotic resistance are easily spread between the environment and humans and infections due to drug resistant organisms contribute to sepsis mortality via delayed time to appropriate antimicrobial therapy. Additionally, second or third-line antibiotics are often not available or are prohibitively expensive in resource-constrained settings leading to limited treatment options. Lack of access to water and sanitation facilities, unregulated use of antibiotics, and malnutrition are contributors to high rates of antibiotic resistance in the region. Improvements in the monitoring of drug resistant infections and antibiotic stewardship are needed to preserve the efficacy of antibiotics for the future.

Keywords: E. coli; Klebsiella pneumoniae; Sub-Sahara Africa; resistance; sepsis.

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Conflict of interest statement

DD has served as a consultant for Achaogen, Allergan, Shionogi, Tetraphase, Pfizer, Merck, T2 Biosystems, Karius, Utility, Entasis, Qpex, and Roche. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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