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. 2021 Jan 8;12(4):299-308.

A systematic review and meta-analysis of laparotomy compared with laparoscopic management of interstitial pregnancy

G Marchand  1 , A Taher Masoud  2 , K Sainz  1 , A Azadi  3 , K Ware  1 , J Vallejo  1 , S Anderson  1 , A King  1 , A Osborn  1 , S Ruther  1 , G Brazil  1 , K Cieminski  1 , S Hopewell  1 , L Rials  1 , D Jenks  4 , A Steele  4 , J Love  4
Affiliations

A systematic review and meta-analysis of laparotomy compared with laparoscopic management of interstitial pregnancy

G Marchand et al. Facts Views Vis Obgyn. .

Abstract

Background: Interstitial pregnancy is a rare but life-threatening condition accounting for 1-4% of all types of tubal ectopic pregnancies. It can be managed by open and minimally invasive surgical techniques. Our goal was to compare laparoscopic and open surgery for managing interstitial pregnancy.

Search strategy: We searched PubMed, Scopus, Web of Science, and Cochrane up to May 2020.

Selection criteria: 1) Women with interstitial pregnancy, 2) Intervention: laparoscopic surgery, 3) Comparator: open surgery, 4) Outcomes: Hospital stay, operation time, pain scale, blood loss. Secondary outcomes: any other reported 5) Study designs: interventional and observational.

Data collection and analysis: Data was extracted from the relevant articles and was pooled as mean difference (MD) or relative risk (RR) with a 95% confidence interval (CI).

Main results: We included six studies, three of which provided eligible data. The duration of hospital stay was lower in the laparoscopic surgery group (MD = -1.42, 95% CI [-1.72, -0.76], P < 0.0001). There was no significant difference in operative time (MD = 5.90, 95% CI [-11.30, 23.09], P = 0.50, blood loss (MD = -9.43, 95% CI [-214.18, 195.32], P = 0.93), complications (RR = 1.54, 95% CI [0.20, 11.85], P = 0.68), or blood transfusions (RR = 0.77, 95% CI [0.50, 1.25], P = 0.30).

Conclusion: Laparoscopic surgery is associated with shorter hospital stay, with no difference in terms of blood loss, post-, and intraoperative complications, and need for blood transfusion compared with laparotomy.

Keywords: Interstitial pregnancy; cornual; ectopic; laparoscopy; laparotomy; meta-analysis.

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Conflict of interest statement

Conflicts of Interest:Authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
PRISMA flow chart
Figure 2
Figure 2
Mean difference (MD) in Postoperative hospital stay.
Figure 3
Figure 3
Mean difference (MD) in Operative Time .
Figure 4
Figure 4
Mean difference (MD) in Blood loss.
Figure 5
Figure 5
Postoperative and intraoperative complications.
Figure 6
Figure 6
Blood Transfusion.
See this image and copyright information in PMC

References

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