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. 2021 Feb 1;4(2):e210337.
doi: 10.1001/jamanetworkopen.2021.0337.

Age- and Sex-Associated Variations in the Sensitivity of Serological Tests Among Individuals Infected With SARS-CoV-2

Rohit Vashisht  1 , Ayan Patel  1   2 , Bridgit O Crews  3 , Omai B Garner  4 , Lisa Dahm  2 , Charles Wilson  2 , Atul J Butte  1   2
Affiliations

Age- and Sex-Associated Variations in the Sensitivity of Serological Tests Among Individuals Infected With SARS-CoV-2

Rohit Vashisht et al. JAMA Netw Open. .

Abstract

This cohort study examines the sensitivity of antibody tests to detect previous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by time, test, sex, and age.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Butte reported receiving grants from the US Food and Drug Administration and Robert Wood Johnson Foundation during the conduct of the study; grants from National Institutes of Health, Genentech, Johnson and Johnson, Leon Lowenstein Foundation, Intervalien Foundation, Priscilla Chan and Mark Zuckerberg, Barbara and Gerson Bakar Foundation, California Governor's Office of Planning and Research, L’Oreal; personal fees from Genentech, Johnson and Johnson, Roche, Pfizer, Merck, Eli Lilly and Company, Takeda Pharmaceutical, Varian Medical Systems, Mars, Siemens, Optum, Abbott Laboratories, Celgene, AstraZeneca, AbbVie, Westat, NuMedii, Personalis, Samsung, Mango Tree, Illumina, Pathway Genomics, 10x Genomics, Helix, Covance, Novartis, Regenstrief Institute, AlphaSights, Gerson Lehman Group, and Geisinger Health; owning shares in Personalis, Samsung, Royalty Pharma, Illumina, Snap, Amazon.com, Microsoft, Alphabet, Facebook, Apple, Sutro Biopharma, Nuna, 10x Genomics, Assay Depot, Regeneron, Sanofi, Vet24seven, AstraZeneca, Moderna, Biogen, and Paraxel; and owing a patent with Stanford University with royalties paid from NuMedii and Personalis and a patent with University of California, San Francisco, pending, outside the submitted work. No other disclosures were reported.

Figures

Figure.
Figure.. Timing and Sensitivity of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Testing
LIAISON SARS-CoV-2 S1/S2 IgG (Diasorin) tests were used February 1 to October 15, 2020; DZ-Lite SARS-CoV-2 IgG CLIA kit (Diazyme), February 1 to August 31, 2020; and Beckman Access SARS-CoV-2 IgG, September 1 to October 15, 2020 (B). RT-PCR indicates reverse transcription–polymerase chain reaction.
See this image and copyright information in PMC

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