Cardiovascular changes during the sleep-wake cycle in spontaneous hypertensive rats and their genetically normotensive precursors

Abstract

Blood pressure and heart rate were recorded in spontaneously hypertensive rats (SH) and in their genetically normotensive precursors (WKY) during the sleep-wake cycle using a computer-assisted method. Similar results were obtained in both strains: (a) No significant difference was observed in blood pressure values between slow-wave-sleep (SWS) and the last 2 min of the preceding wakefulness (W) episode within the complete cycle; blood pressure then increased during PS. (b) Heart rate values during SWS were significantly lower than those computed for W; a further fall of heart rate was observed during paradoxical sleep (PS) only in hypertensive rats. (c) During SWS the blood pressure and heart rate variability was significantly lower than during W and PS. In addition, blood pressure variability values during the three sleep-wake states were lower in hypertensive than in normotensive rats. These data suggest that there are no qualitative differences in the mechanisms that control circulation during sleep in normotensive and spontaneous hypertensive rats.