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Comment
. 2021 Mar 8;39(3):299-301.
doi: 10.1016/j.ccell.2021.02.001. Epub 2021 Feb 11.

The power to "di-sc-seq-t"

Anne M van der Leun  1 , John B Haanen  2
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The power to "di-sc-seq-t"

Anne M van der Leun et al. Cancer Cell. .
Free article

Abstract

In melanoma, intratumoral T-VEC is thought to work through viral replication and destruction of cancer cells, thereby stimulating an immune response. In this issue of Cancer Cell, Ramelyte et al. show activity of T-VEC in cutaneous B cell lymphoma and demonstrate, using scRNA-seq, that viral replication occurs not only in tumor cells.

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Conflict of interest statement

Declaration of interests J.B.H. has received (institutional) financial compensation for advisory roles for Achilles Therapeutics, BioNTech, BMS, Gadeta, Immunocore, MSD, Merck Serono, Molecular Partners, Neogene Therapeutics, Novartis, Pfizer, Roche/Genentech, Sanofi, Seattle Genetics, and Third Rock Ventures. J.B.H. received institutional research grants from Amgen, BioNTech, BMS, MSD, and Novartis. J.B.H. holds stock options for Neogene Therapeutics.

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